| 100% | BARDEM | 6 | Javier ___, Spanish actor who played the Bond villain in the movie "Skyfall" |
| 74% | WALTZ | 5 | Christoph ___, German-Austrian actor who played the Bond villain in the movie "Spectre" |
| 63% | LEE | 3 | Christopher ___, English actor who played the Bond villain in "The Man with the Golden Gun" |
| 62% | WALKEN | 6 | Christopher ___, American actor who played the Bond villain in "A View to a Kill" |
| 59% | RAULJULIA | 9 | "The Addams Family" actor who played the villain Bison in the 1994 video-game movie "Street Fighter": 2 wds. |
| 58% | JONATHANPRYCE | 13 | "Pirates of the Caribbean" actor who played a Bond villain in 1997's "Tomorrow Never Dies": 2 wds. |
| 57% | BARDEM | 6 | Javier __, Spanish actor, the villain in Skyfall |
| 56% | RALPH | 5 | ___ Fiennes, English actor who played the role of Gareth Mallory in James Bond movies |
| 56% | MADSMIKKELSEN | 13 | "Doctor Strange" actor who plays the villain in the new 17-Across movie: 2 wds. |
| 55% | MYERS | 5 | Mike ___, actor who played the role of the hero and the villain in the movie "Austin Powers" |
| 54% | JIMCARREY | 9 | "The Mask" actor who plays the villain Dr. Robotnik in the 2020 video-game movie "Sonic the Hedgehog": 2 wds. |
| 54% | MATHIEU | 7 | Amalric who played the Bond villain in Quantum of Solace |
| 54% | EVA | 3 | ___ Green, actor who played the Bond girl in "Casino Royale" |
| 54% | DENNIS | 6 | With 34-Across, "Speed" actor who played the villain President Koopa in the 1993 video-game movie "Super Mario Bros." |
| 54% | ROBERTCARLYLE | 13 | "Once Upon a Time" actor who played a Bond villain in 1999's "The World Is Not Enough": 2 wds. |
| 53% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 53% | DEPP | 4 | Actor Johnny who played the Mad Hatter in two movies |
| 53% | MARKRUFFALO | 11 | Actor who played the Hulk in the Avengers movies: 2 wds. |
| 53% | REBBROWN | 8 | Actor who played the titular character in the TV movie "Captain America" in 1979: 2 wds. |
| 52% | MADSMIKKELSEN | 13 | "Hannibal" actor who played a Bond villain in 2006's "Casino Royale": 2 wds. |
| 52% | RALPH | 5 | ___ Fiennes, actor who plays head of MI6 in the movie "No Time to Die" |
| 52% | DAVID | 5 | ___ Ackroyd, actor who played the titular character in the TV movie "Exo-Man" in 1977 |
| 52% | FERDIASHAW | 10 | Young actor who plays the title character in the 2020 movie "Artemis Fowl": 2 wds. |
| 52% | LETO | 4 | Actor Jared ___, who played a transgender woman in the movie "Dallas Buyers Club" |
| 52% | TOMCRUISE | 9 | Actor who plays agent Ethan Hunt in the "Mission: Impossible" movies: 2 wds. |
| 52% | MICHAELPENA | 11 | "Narcos: Mexico" actor who plays Dora's father in the movie mentioned in 33a: 2 wds. |
| 51% | MADSMIKKELSEN | 13 | "Hannibal" actor who plays the villain Kaecilius in 32-Across: 2 wds. |
| 51% | BANA | 4 | Actor who played the villain in 2009's "Star Trek" |
| 51% | MICHAELGROSS | 12 | Actor who played Burt Gummer in both the movie and TV series "Tremors": 2 wds. |
| 51% | GARY | 4 | ___ Sinise, actor who played Lieutenant Dan Taylor in the 1994 movie "Forrest Gump" |