| 100% | MOHR | 4 | Jay who was the first host of "Last Comic Standing" |
| 61% | DAVID | 5 | Letterman who was the first host of 15-Across |
| 60% | ALLEN | 5 | Steve who was the first host of "The Tonight Show" |
| 60% | REGIS | 5 | Philbin who was the first host of "America's Got Talent" |
| 60% | CHARLESKURALT | 13 | Journalist who was the first host of 48-Across (2 wds.) |
| 60% | MEL | 3 | Allen who was the first host of "This Week in Baseball" |
| 60% | CHEVYCHASE | 10 | Comedian who was the first host of 31-Across (2 wds.) |
| 58% | JENNADEWAN | 10 | "Step Up" actress who was the first host of "World of Dance": 2 wds. |
| 57% | LENO | 4 | Jay who was the late-night host before Jimmy Fallon |
| 55% | CANDICEBERGEN | 13 | Actress who was the first female host of "Saturday Night Live": 2 wds. |
| 54% | CANDICEBERGEN | 13 | "Murphy Brown" star who was the first female host of "Saturday Night Live": 2 wds. |
| 52% | JOAN | 4 | ___ Rivers, comedian and actress who was the first woman to host a late-night network TV talk show |
| 52% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 49% | TINAFEY | 7 | Actress/writer who was the first woman to be head writer of "Saturday Night Live," and the third woman to host five times (2 wds.) |
| 48% | MOHR | 4 | Jay who once hosted "Last Comic Standing" |
| 48% | JADA | 4 | First name of Will Smith's wife, who hosts the Facebook show "Red Table Talk" |
| 48% | INDIRA | 6 | Gandhi who was the first female PM of India |
| 47% | SEAN | 4 | Parker who was the first president of Facebook |
| 47% | ROLLO | 5 | Viking who was the first ruler of Normandy |
| 47% | PELOSI | 6 | Congresswoman Nancy who was the first female Speaker of the House |
| 47% | RICE | 4 | Condoleezza who was the first female African-American secretary of state |
| 47% | TOM | 3 | Landry who was the first coach of the Cowboys |
| 47% | RIDGE | 5 | Tom who was the first Secretary of Homeland Security |
| 46% | BEV | 3 | Politician Perdue who was the first woman elected governor of North Carolina |
| 46% | MARSAIMARTIN | 12 | Producer who was the first cover star of Essence's Girls United |
| 46% | EMIL | 4 | Comedian Wakim who is the first Lebanese American cast member of "SNL" |
| 46% | MOHR | 4 | Comedian/actor Jay who hosted "Last Comic Standing" |
| 46% | ANNE | 4 | Robinson who was the original host of "The Weakest Link" |
| 46% | KASEM | 5 | Casey who was the longtime host of "American Top 40" |
| 46% | EVA | 3 | Perón who was the First Lady of Argentina |