| 100% | BRETT | 5 | Jeremy ___, 1980s-'90s portrayer of Sherlock Holmes |
| 51% | MORIARTY | 8 | Arch-enemy of Sherlock Holmes |
| 50% | ASTUDYINSCARLET | 15 | Debut of Sherlock Holmes |
| 50% | DOYLE | 5 | Creator of Sherlock Holmes |
| 50% | MYCROFT | 7 | Brother of Sherlock Holmes |
| 49% | ARTHUR | 6 | Sir __ Conan Doyle, writer of Sherlock Holmes |
| 49% | DOYLE | 5 | Sir Arthur Conan ___, creator of Sherlock Holmes |
| 49% | IRENE | 5 | Adler of Sherlock Holmes stories |
| 49% | MYCROFT | 7 | Elder brother of Sherlock Holmes |
| 49% | ACD | 3 | Monogram of Sherlock Holmes' creator |
| 49% | IRENE | 5 | Adler of Sherlock Holmes fame |
| 49% | BASILRATHBONE | 13 | Sherlock Holmes portrayer |
| 48% | DEERSTALKER | 11 | Part of Sherlock Holmes's attire |
| 48% | DOYLE | 5 | Arthur Conan ___ (creator of Sherlock Holmes) |
| 48% | ARTHUR | 6 | ___ Conan Doyle, creator of Sherlock Holmes |
| 48% | SCOTLAND | 8 | __ Yard, workplace of Sherlock Holmes' Lestrade |
| 47% | INSPECTOR | 9 | Lestrade of Sherlock Holmes stories, e.g. |
| 47% | ADLER | 5 | Irene who's a frenemy of Sherlock Holmes |
| 47% | BASILRATHBONE | 13 | Sherlock Holmes portrayer in 14 movies |
| 47% | BASILRATHBONE | 13 | Sherlock Holmes portrayer in 15 movies |
| 46% | NATE | 4 | With 20-Down, kiddie-lit counterpart of Sherlock Holmes |
| 46% | BASIL | 5 | First name of Sherlock Holmes actor from the 1940s |
| 46% | MORIARTY | 8 | Sherlock Holmes' adversary, the Napoleon of Crime |
| 45% | SIR | 3 | ___ Arthur Conan Doyle (title for the creator of Sherlock Holmes) |
| 44% | CLIVE | 5 | ___ Merrison, actor known for his BBC Radio portrayal of Sherlock Holmes |
| 44% | NIGEL | 5 | Actor Bruce who played Watson in "The New Adventures of Sherlock Holmes" |
| 44% | MORIARTY | 8 | Professor James —, archenemy of Sherlock Holmes in tales by Arthur Conan Doyle |
| 43% | MORIARTY | 8 | Professor James —, arch-enemy of Sherlock Holmes in stories by Arthur Conan Doyle |
| 43% | ENOLA | 5 | Sherlock Holmes's younger sister in a series of YA novels |
| 41% | BELL | 4 | Joseph ___, surgeon whom Arthur Conan Doyle cites as inspiration for the character of Sherlock Holmes |