| 100% | MEIR | 4 | Jessica ___, astronaut who participated in the first all-female spacewalk |
| 49% | EVA | 3 | Spacewalk performed by the first all-female team in 2019 (Abbr.) |
| 43% | MAEJEMISON | 10 | The first Black female astronaut and winner of a National Achievement Scholarship in 1973: 2 wds. |
| 43% | SWAM | 4 | Participated in the first third of a triathlon |
| 42% | KALPANA | 7 | ___ Chawla, American astronaut who became the first Indian woman to fly in space in 1997 |
| 42% | SALLY | 5 | ___ Ride, American astronaut who became the first American woman to fly in space in 1983 |
| 42% | WHITSON | 7 | Peggy ___, American astronaut who became the first woman to command the International Space Station in 2007 |
| 42% | EILEEN | 6 | ___ Collins, American astronaut who became the first woman to command a space shuttle mission in 1999 |
| 42% | MAE | 3 | ___ Jemison, American astronaut who became the first African-American woman to travel to space in 1992 |
| 41% | ALI | 3 | Boxer who participated in the "Rumble in the Jungle" |
| 41% | OCHOA | 5 | Astronaut Ellen who was the first Latina in space |
| 41% | ALAN | 4 | Astronaut Shepard who was the first American in space |
| 41% | ELLEN | 5 | Astronaut Ochoa who was the first Latina in space |
| 41% | INDIRA | 6 | Gandhi who was the first female PM in India |
| 40% | RIDE | 4 | Astronaut Sally who was the first American woman in space |
| 40% | MAE | 3 | Astronaut Jemison who was the first Black woman in space |
| 40% | OCHOA | 5 | Astronaut Ellen who was the first Hispanic woman in space |
| 40% | MAE | 3 | Astronaut Jemison who was the first African-American woman in space |
| 40% | CNN | 3 | The first all-news channel in the United States |
| 38% | CHRISTINA | 9 | __ Koch, astronaut on first all-female spacewalk |
| 38% | NANCYDREW | 9 | Fictional young female detective who first appeared in a 1930 book credited to the pen name Carolyn Keene: 2 wds. |
| 37% | TONIMORRISON | 12 | Author who received the Nobel Prize in Literature on the basis of her first six novels, all featured in this puzzle |
| 37% | RABBI | 5 | The first ordained female one was Regina Jonas in 1935 |
| 37% | BLACKWELL | 9 | Elizabeth, the first female doctor in the US |
| 37% | WHITTAKER | 9 | Jodie __, she plays the first female Doctor Who |
| 37% | JANE | 4 | Fred T. ___, who first published "All the World's Fighting Ships" in 1898 |
| 37% | BEAN | 4 | Sean who starred in the first season of "Game of Thrones" |
| 36% | ELMO | 4 | Red Muppet who first appeared in the "Sesame Street" song "We Are All Monsters" |
| 36% | JODIE | 5 | ___ Whittaker, player of the first female Doctor on "Doctor Who" |
| 36% | EVE | 3 | Female rapper who starred in the "Barbershop" films |