| 100% | UNCLEBUCK | 9 | John Candy family comedy set in a Chicago suburb (2 wds.) |
| 68% | RISKYBUSINESS | 13 | Tom Cruise teen comedy set in a Chicago suburb (2 wds.) |
| 68% | HOMEALONE | 9 | Macaulay Culkin Christmas comedy set in a Chicago suburb (2 wds.) |
| 43% | SOUTHPARK | 9 | Animated Comedy Central series set in a small town in Colorado: 2 wds. |
| 43% | NURSEJACKIE | 11 | Showtime comedy-drama set in a hospital that ended this summer: 2 wds. |
| 41% | FAMILYMATTERS | 13 | Sitcom set in Chicago that was a spin-off of "Perfect Strangers" (2 wds.) |
| 39% | THEJEFFERSONS | 13 | Sitcom set in New York city that was a spin-off of "All in the Family" (2 wds.) |
| 39% | ORANGEIS | 8 | With 33- and 52-Across, television series set in a women's prison: 2 wds. |
| 38% | UNCLEBUCK | 9 | 1989 John Hughes comedy starring John Candy as a crude babysitter: 2 wds. |
| 38% | JULIANNEMOORE | 13 | "Still Alice" actress who was raised in a military family: 2 wds. |
| 38% | SALADFORK | 9 | Utensil on the far left in a standard place setting: 2 wds. |
| 38% | CHARLIEWILSON | 13 | Title role played by Tom Hanks in a 2007 comedy-drama: 2 wds. |
| 38% | LARRYCROWNE | 11 | Title role played by Tom Hanks in a 2011 romantic comedy: 2 wds. |
| 38% | DONALDGLOVER | 12 | Emmy winner for Outstanding Lead Actor in a Comedy for "Atlanta": 2 wds. |
| 37% | JUDDHIRSCH | 10 | 1981 Emmy winner for "Taxi" (Outstanding Lead Actor In a Comedy Series): 2 wds. |
| 37% | NEWTGINGRICH | 12 | Former Speaker of the House who was raised in a military family: 2 wds. |
| 37% | MICHAELSTIPE | 12 | R.E.M. front man who was raised in a military family: 2 wds. |
| 37% | ALLTHAT | 7 | "She's ___," 1999 rom-com set in a high school featuring Freddie Prinze Jr. and Rachael Cook: 2 wds. |
| 37% | THEGOODFIGHT | 12 | CBS All Access series set in the world of a Chicago law firm: 3 wds. |
| 37% | GEORGEJETSON | 12 | Elroy and Judy's father in a classic cartoon about a futuristic family: 2 wds. |
| 37% | ERICMCCORMACK | 13 | 2001 Emmy winner, Outstanding Lead Actor in a Comedy Series (for "Will & Grace"): 2 wds. |
| 37% | BLADERUNNER | 11 | 1982 science fiction film set in a dystopian future Los Angeles and about synthetic humans known as replicants: 2 wds. |
| 36% | ARMYBRAT | 8 | Kid in a military family (2 wds.) |
| 36% | DONALDGLOVER | 12 | Actor who won the Emmy for Outstanding Lead Actor in a Comedy for "Atlanta": 2 wds. |
| 36% | SCHITTSCREEK | 12 | Sitcom set in Canada with a 2020 same-sex wedding between David and Patrick: 2 wds. |
| 36% | THEMAGICIANS | 12 | Lev Grossman novel set in a school for aspiring sorcerers (2 wds.) |
| 36% | THEGOLDBERGS | 12 | ABC comedy series set in the 1980s: 2 wds. |
| 36% | PLAYMONEY | 9 | Cash in a Monopoly set, for example: 2 wds. |
| 36% | GOODTIMES | 9 | 1970s sitcom set in a Chicago housing project |
| 36% | SING | 4 | 2016 animated musical comedy set in a theater |