| 100% | ALCOCK | 6 | John W —, English aviator who, with A W Brown, made the first non-stop flight across the Atlantic |
| 47% | BLERIOT | 7 | Louis —, French aviator who made the first flight across the English Channel |
| 33% | AMELIA | 6 | Earhart who was the first female aviator to fly solo across the Atlantic |
| 33% | POST | 4 | Wiley —, US aviator who made the first solo flight around the world in 1933 |
| 33% | AMELIA | 6 | American aviator ___ Earhart who was the first female aviator to fly solo across the Atlantic Ocean |
| 32% | EARHART | 7 | Amelia —, first woman to fly solo non-stop across the Atlantic |
| 31% | GAGARIN | 7 | Yuri —, Soviet cosmonaut who made the first manned space flight in 1961 |
| 31% | AMELIAEARHART | 13 | First female aviator to fly solo across the Atlantic: 2 wds. |
| 30% | BYRD | 4 | Explorer Richard who made the first flight over the South Pole |
| 30% | FELICITY | 8 | With 55-Across, English actress who plays the first wife of 35-Across in "The Theory of Everything" |
| 29% | PAGE | 4 | Actress Ellen who made her first foray into horror with the "Flatliners" reboot |
| 29% | ARI | 3 | Hollywood agent Emanuel who shares a first name with the "Entourage" character he inspired |
| 29% | JENNIFERLOPEZ | 13 | 15-Across and 27-Across singer who was the first woman honored with a "Billboard" Icon Award (2 wds) |
| 28% | ROWLEY | 6 | William —, English dramatist who collaborated with Thomas Middleton on The Changeling and A Fair Quarrel |
| 28% | AMELIA | 6 | Earhart, the first female aviator to fly solo across the Atlantic |
| 28% | GENE | 4 | NASA Flight Director Kranz who directed Apollo 11's mission to make the first lunar landing |
| 28% | CHAR | 4 | Actor who played a character with the same first name on "Two and a Half Men" |
| 28% | ELVISCOSTELLO | 13 | English rock singer who shares a first name with earlier singer Presley: 2 wds. |
| 28% | AMELIA | 6 | Earhart who was the first aviatrix to fly solo across the Atlantic |
| 28% | GHOSTFACE | 9 | Antagonist with a mask in the "Scream" movies who made everyone scream |
| 28% | HARRIETQUIMBY | 13 | First woman to earn a pilot's license in the United States and the first woman to fly across the English Channel (2 wds.) |
| 28% | FAUST | 5 | Goethe character who makes a pact with the devil |
| 27% | LETSSEEWHATS | 12 | With 90 Across, the most famous line heard on Let's Make a Deer? |
| 27% | FAUST | 5 | Classic literary character who makes a deal with the devil |
| 27% | CHLOEZHAO | 9 | 16-Across director who won an Academy Award for Best Director in 2021, becoming the first non-white woman to win a directing Oscar (2 wds.) |
| 27% | AMELIAEARHART | 13 | Aviation pioneer who was the first woman to fly solo across the Atlantic: 2 wds. |
| 27% | TONYDUNGY | 9 | Hall-of-Famer who was the first Black head coach to win a 15 Across |
| 27% | KRONFELD | 8 | Robert —, Austria-born sailplane designer; first pilot to fly a glider across the English Channel |
| 27% | SWOOPES | 7 | Sheryl who was the first W.N.B.A. player to have a signature shoe |
| 27% | WYCLIFFE | 8 | John ___, English philosopher and theologian who made an early translation of the Bible |