| 100% | BELL | 4 | Joseph ___, surgeon whom Arthur Conan Doyle cites as inspiration for the character of Sherlock Holmes |
| 44% | SIR | 3 | ___ Arthur Conan Doyle (title for the creator of Sherlock Holmes) |
| 35% | ELEMENTARY | 10 | CBS detective series based on the characters of Arthur Conan Doyle |
| 34% | MORIARTY | 8 | Professor James —, archenemy of Sherlock Holmes in tales by Arthur Conan Doyle |
| 34% | MORIARTY | 8 | Professor James —, arch-enemy of Sherlock Holmes in stories by Arthur Conan Doyle |
| 33% | ARTHUR | 6 | Sir ___ Conan Doyle, creator of "Sherlock Holmes" who went to the University of Edinburgh Medical School |
| 33% | FOUR | 4 | "The Sign of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 33% | BASKERVILLES | 12 | "The Hound of the ___," Sherlock Holmes novel by Arthur Conan Doyle |
| 32% | LOST | 4 | "The ___ World," first book featuring the character of Professor Challenger created by Arthur Conan Doyle |
| 31% | LESTRADE | 8 | Fictional Scotland Yard inspector in stories by Arthur Conan Doyle involving Sherlock Holmes who first appeared in A Study in Scarlet |
| 31% | SIGNOFFOUR | 10 | The —, 1890 novel by Arthur Conan Doyle featuring Sherlock Holmes |
| 31% | ELEMENTARY | 10 | TV series with Jonny Lee Miller and Lucy Liu which is a modern-day take on Sir Arthur Conan Doyle's character Sherlock Holmes |
| 31% | BAND | 4 | "The Adventure of the Speckled ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 30% | STONE | 5 | "Rodney ___," gothic mystery novel by Arthur Conan Doyle that was adapted as "The House of Temperley" |
| 30% | IRENEADLER | 10 | Holmes character created by Arthur Conan Doyle who may be modeled after Lillie Langtry or Lola Montez |
| 30% | IRENEADLER | 10 | Fictional opera singer/actress who outsmarts Sherlock Holmes in the Arthur Conan Doyle story "A Scandal in Bohemia" (2 wds.) |
| 29% | SILVERBLAZE | 11 | 1892 story by Arthur Conan Doyle featuring detective Sherlock Holmes |
| 29% | BAKERSTREET | 11 | & 1A Group of street urchins who aid Sherlock Holmes in various stories by Arthur Conan Doyle |
| 28% | EGYPT | 5 | Land serving as inspiration for "The Mummy" characters |
| 27% | DOYLE | 5 | Arthur Conan ___ (creator of Sherlock Holmes) |
| 27% | POE | 3 | Edgar Allan ___, author who created the character of C. Auguste Dupin, a precursor to Sherlock Holmes |
| 27% | ARTHUR | 6 | ___ Conan Doyle, creator of Sherlock Holmes |
| 26% | SETH | 4 | Macfarlane who cites Rex Harrison as the inspiration for Stewie's voice on "Family Guy" |
| 26% | PIPS | 4 | "The Five Orange ___," Sherlock Holmes short story by Arthur Conan Doyle |
| 26% | ASTUDYIN | 8 | & 16D First of four Sherlock Holmes novels by Arthur Conan Doyle, published in book form in 1888 |
| 26% | SHERLOCK | 8 | __ Holmes, character by Sir Arthur Conan Doyle |
| 26% | SANSA | 5 | "Game of Thrones" character who winds up as Queen of the North |
| 26% | FINAL | 5 | & 16A The —, Sherlock Holmes story by Arthur Conan Doyle first published in the Strand Magazine in December 1893 |
| 26% | ARTHUR | 6 | Sir __ Conan Doyle, writer of Sherlock Holmes |
| 25% | LISTER | 6 | Joseph —, British surgeon who introduced the use of antiseptics |