| 100% | COURIC | 6 | Journalist who was the first woman to guest-host "Jeopardy!" |
| 98% | KATIECOURIC | 11 | Journalist who was the first woman to guest-host "Jeopardy!" (2 wds.) |
| 68% | JOAN | 4 | ___ Rivers, comedian and actress who was the first woman to host a late-night network TV talk show |
| 68% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 67% | CANDICEBERGEN | 13 | Actress who was the first woman to host "Saturday Night Live," and the first woman to host five times (2 wds.) |
| 65% | TINAFEY | 7 | Actress/writer who was the first woman to be head writer of "Saturday Night Live," and the third woman to host five times (2 wds.) |
| 65% | AARONRODGERS | 12 | Green Bay Packers quarterback who was the first NFL star to guest-host "Jeopardy!" (2 wds.) |
| 65% | LEVARBURTON | 11 | "Reading Rainbow" host who was the first Grammy winner to guest-host "Jeopardy!" (2 wds.) |
| 63% | REBA | 4 | Singer McEntire who was the first woman to play Colonel Sanders |
| 62% | JEN | 3 | Cartoonist Sorensen who was the first woman to win the Herblock Prize |
| 62% | ZAHA | 4 | Hadid who was the first woman to win the Pritzker Architecture Prize |
| 62% | VINCE | 5 | Environmental journalist Gaia ___ who was the first woman to win the Royal Society Winton Prize for Science Books |
| 62% | EDITH | 5 | Wharton who was the first woman to win the Pulitzer Prize for Literature |
| 62% | ROSA | 4 | Parks who was the first woman to lie in honor in the Capitol |
| 62% | EDITH | 5 | Wharton who was the first woman to win a Pulitzer Prize for fiction |
| 62% | RENO | 4 | Janet who was the first woman to serve as U.S. attorney general |
| 62% | CHARLESKURALT | 13 | Journalist who was the first host of 48-Across (2 wds.) |
| 61% | MARYAM | 6 | ___ Mirzakhani, an Iranian mathematician who was the first woman to receive the Fields Medal |
| 61% | ITO | 3 | Olympic skater who was the first woman to land a triple axel in competition |
| 61% | ITO | 3 | Skater Midori who was the first woman to land a triple axel in competition |
| 61% | REBA | 4 | McEntire who is the first woman to portray Colonel Sanders in a KFC ad |
| 61% | RANKIN | 6 | Jeannette who was the first woman elected to Congress (1916) |
| 61% | ANN | 3 | Explorer Bancroft who was the first woman to complete an expedition to the North Pole |
| 61% | AMELIAEARHART | 13 | Aviation pioneer who was the first woman to fly solo across the Atlantic: 2 wds. |
| 61% | ANNE | 4 | Sci-fi writer McCaffrey, who was the first woman to win a Hugo for fiction |
| 60% | SHERYLSWOOPES | 13 | Openly gay basketballer who was the first woman to be signed by the WNBA: 2 wds. |
| 60% | BLACKWELL | 9 | Elizabeth ___, British physician who was the first woman to earn a medical degree in the US |
| 60% | ANNMEYERS | 9 | Basketball Hall-of-Famer who was the first woman to sign an N.B.A. contract |
| 60% | ELAYNE | 6 | Boosler who was the first woman to have an hour-long comedy special on cable TV |
| 60% | SAHLE | 5 | ___-Work Zewde, Ethiopian politician who is the first woman to serve as the President of Ethiopia |