| 100% | APATOW | 6 | Judd, director of Knocked Up and This Is 40 |
| 52% | APATOW | 6 | "This Is 40" and "The 40-Year-Old Virgin" director Judd |
| 51% | ROBREINER | 9 | Director of films LBJ and This Is Spinal Tap |
| 46% | PAULRUDD | 8 | Star of Ant-Man and This Is 40 |
| 46% | IJUSTMETYOU | 11 | "Hey, ___, and this is crazy ..." (start of the chorus in 40-Across): 4 wds. |
| 46% | APATOW | 6 | “This Is 40” director Judd |
| 44% | APATOW | 6 | Director of the 2012 comedy "This Is 40" |
| 42% | APATOW | 6 | Director of "The 40-Year-Old Virgin" and "This Is 40" |
| 40% | APATOW | 6 | Judd who directed "Knocked Up" and "The 40-Year-Old Virgin" |
| 40% | OXYGEN | 6 | Air is made up of mostly nitrogen and this gas |
| 40% | TIC | 3 | With 40- and 43-Across, game that's been played in each of this puzzle's corners |
| 39% | DALES | 5 | Ups and downs are hills and these |
| 39% | MANN | 4 | Leslie ___, an actress known for her roles in "This is 40" and "George of the Jungle" |
| 38% | REDWINE | 7 | The bottle of Chateau Margaux 1787, insured for $225,000 and knocked over by a waiter, was this type of beverage |
| 38% | ECLIPSE | 7 | This was Total and of the Heart, for Bonnie Tyler |
| 37% | APATOW | 6 | Judd who directed "This Is 40" and "The 40-Year-Old Virgin" |
| 37% | KEEPTHEFAITH | 12 | 1992 Bon Jovi album whose three Top 40 hits were the title track, "Bed of Roses," and "In These Arms" (3 wds.) |
| 36% | BENIGNI | 7 | Director and star of Life is Beautiful: Roberto __ |
| 36% | JUDD | 4 | "This Is 40" director ___ Apatow |
| 36% | ANDERSON | 8 | Lindsay —, director of the films Britannia Hospital and This Sporting Life |
| 35% | ONES | 4 | "Binary system is made up of ___ and zeros." |
| 35% | ISLANDS | 7 | Hawaii is made up of these land masses |
| 35% | SHIA | 4 | Zaydism and Isma'ilism are sects of this |
| 35% | STRIKES | 7 | Three of these and the batter is out |
| 35% | AGENCIES | 8 | HMRC and the CIA are examples of these |
| 35% | DESSERTS | 8 | Cheesecake and ice cream are examples of these |
| 35% | THEYD | 5 | "And this was scarcely odd, because ___ eaten every one" (end of "The Walrus and the Carpenter") |
| 35% | JOHNSINGLETON | 13 | Director of 18-Across and 40-Across who passed away in 2019 (2 wds.) |
| 35% | PROPERTY | 8 | Goal of Monopoly is to buy all this up |