| 100% | CHARLOTTESWEB | 13 | Julia Roberts/Dakota Fanning film based on a novel by E.B. White (2 wds.) |
| 59% | CHARLOTTESWEB | 13 | 2006 Julia Roberts kids' movie, based on an E.B. White novel, whose title begins with a woman's name: 2 wds. |
| 52% | ANNAKARENINA | 12 | Keira Knightley film based on a novel by Leo Tolstoy (2 wds.) |
| 52% | THEAFTERMATH | 12 | Keira Knightley film based on a novel by Rhidian Brook (2 wds.) |
| 52% | THEGOLDFINCH | 12 | 2019 film based on a 2013 best-selling novel by Donna Tartt: 2 wds. |
| 51% | THEFIRM | 7 | American legal thriller film based on a John Grisham novel by the same name: 2 wds. |
| 51% | LOVEYOU | 7 | "P.S. I ___," film based on a novel which shares its title with a 1962 song by The Beatles: 2 wds. |
| 49% | NEVERLETMEGO | 12 | Keira Knightley film based on a novel by Kazuo Ishiguro (4 wds.) |
| 49% | TREASURE | 8 | & 1D 2002 animated film based on a novel by Robert Louis Stevenson |
| 48% | THEWIZARDOFOZ | 13 | 1939 film based on a novel by L. Frank Baum (4 wds.) |
| 46% | THEALIENIST | 11 | American period drama TV series starring Dakota Fanning which is based on a novel of the same name by Caleb Carr: 2 wds. |
| 46% | SCHINDLERSLIST | 14 | Steven Spielberg film based on a 1982 Thomas Keneally novel: 2 wds. |
| 46% | BLADERUNNER | 11 | 1982 Harrison Ford sci-fi film based on a Philip K. Dick novel: 2 wds. |
| 44% | FAIRLADY | 8 | Musical based on a novel by George Bernard Shaw, "My ___" was the longest-running Broadway show between 1956 - 1962: 2 wds. |
| 44% | SHUTTERISLAND | 13 | Leonardo DiCaprio psychological thriller based on a novel by Dennis Lehane (2 wds.) |
| 44% | CHARLOTTESWEB | 13 | Children's novel by E.B. White featuring a talking spider and a "Terrific" pig named Wilbur (2 wds.) |
| 43% | SHANE | 5 | 1953 Oscar-nominated film based on a novel by Jack Schaefer |
| 43% | THEREVENANT | 11 | Leonardo DiCaprio drama based on a novel by Michael Punke and a 1915 poem (2 wds.) |
| 43% | ROOM | 4 | Brie Larson Oscar-winning film based on a novel by 29-Across |
| 42% | STUARTLITTLE | 12 | Children's novel by E.B. White featuring a boy who is two inches tall and looks like a mouse (2 wds.) |
| 42% | LESMISERABLES | 13 | Hugh Jackman and 49-Across film based on a Victor Hugo novel (2 wds.) |
| 42% | DOUBTFIRE | 9 | "Mrs. ___," comedy-drama film based on a novel by Anne Fine starring Robin Williams |
| 42% | HOME | 4 | "Miss Peregrine's ___ for Peculiar Children," fantasy film based on a novel by Ransom Riggs |
| 42% | FORRESTGUMP | 11 | Tom Hanks' 1994 drama film based on a Winston Groom novel of the same name in which 20a plays his love interest: 2 wds. |
| 41% | ALTEREDCARBON | 13 | American dystopian sci-fi TV series starring Joel Kinnaman which is based on a novel of the same name by Richard K. Morgan: 2 wds. |
| 41% | THEUNDOING | 10 | 2020 HBO show created by David E. Kelley, based on a Jean Hanff Korelitz novel: 2 wds. |
| 41% | CURIOUSGEORGE | 13 | Will Ferrell film based on a story series by H.A. Rey and Margret Rey (2 wds.) |
| 41% | HIGHFIDELITY | 12 | Film based on a Nick Hornby novel set in a record shop starring John Cusack and Joan Cusack (2 wds.) |
| 40% | GOODOMENS | 9 | Amazon series starring 15-Across/17-Across and 45-Across/47-Across based on a novel by Terry Pratchett and Neil Gaiman (2 wds.) |