| 100% | GUARINI | 7 | Justin, who was the first American Idol runner-up |
| 57% | SHEPARD | 7 | Alan who was the first American in space |
| 57% | ALAN | 4 | Astronaut Shepard who was the first American in space |
| 57% | SALLY | 5 | ___ Ride who was the first American woman in space |
| 56% | GLENN | 5 | John who was the first American to orbit the earth |
| 56% | RIDE | 4 | Astronaut Sally who was the first American woman in space |
| 55% | HALLEBERRY | 10 | "Swordfish" actress who was the first runner-up in the Miss USA pageant in 1986: 2 wds. |
| 55% | RONDA | 5 | Rousey who was the first American woman to win an Olympic judo medal |
| 54% | TALLCHIEF | 9 | Maria who was the first Native American prima ballerina |
| 54% | JANEADDAMS | 10 | Social worker who was the first American woman to win the Nobel Peace Prize |
| 53% | DIA | 3 | Frampton who was runner-up on the first season of "The Voice" |
| 53% | BUCK | 4 | O'Neil who was the first African American coach in the MLB |
| 53% | LIN | 3 | Jeremy who was the first Asian American to win an NBA Championship |
| 53% | EMIL | 4 | Comedian Wakim who is the first Lebanese American cast member of "SNL" |
| 53% | OTT | 3 | Mel who was the first NL player to surpass 500 home runs |
| 52% | SUNILEE | 7 | Gymnast who was the first Hmong American athlete to compete in the Olympics |
| 52% | GERE | 4 | Richard who was the first man featured on the cover of American Vogue |
| 52% | ETHEL | 5 | Waters who was the first Black American to host a national television show |
| 52% | POITIER | 7 | Sidney who was the first African American to win a Best Actor Oscar |
| 52% | OTT | 3 | Mel who was the first N.L.'er to hit 500 home runs |
| 52% | BUNCHE | 6 | Ralph who was the first African American to be awarded the Nobel Peace Prize |
| 52% | ANNE | 4 | Bradstreet who was the first published writer from England's North American colonies (1650) |
| 52% | STEVEN | 6 | Yeun who was the first Asian American nominated for Best Actor (2020's "Minari") |
| 52% | AARON | 5 | Yankee slugger Judge who was the first rookie to win the Home Run Derby |
| 51% | SEATTLESLEW | 11 | 1977 Triple Crown winner who was the first American champion to have been undefeated in previous races: 2 wds. |
| 51% | LINDSEY | 7 | ___ Vonn, former alpine ski racer who was the first American woman to win an Olympic gold in downhill skiing |
| 51% | VIOLA | 5 | Actress Davis who was the first African American to win the Triple Crown of Acting |
| 51% | AVA | 3 | Director DuVernay who was the first African American woman nominated for a Best Picture Oscar |
| 51% | SINCLAIRLEWIS | 13 | Minnesota novelist and short story writer who was the first American honored with the Nobel Prize in Literature (2 wds.) |
| 51% | GALILEO | 7 | Astronomer who was the first to discover that the Milky Way was made up of stars |