| 100% | COOK | 4 | Karen Mixon ___, DJ who became the first professional female DJ for disco clubs |
| 45% | CARDI | 5 | ___ B, hip hop star who became the first female rapper to win a Grammy for Best Rap Album |
| 37% | RUTHELIZABETH | 13 | "Jezebel" actress ___ "Bette" Davis who became the first female recipient of the AFI Life Achievement Award: 2 wds. |
| 36% | RAMIMALEK | 9 | Actor who became the first one of Egyptian heritage to win an Oscar for Best Actor in 2019: 2 wds. |
| 35% | JLO | 3 | Nickname for the female singer who became an "American Idol" judge in 2011: 2 wds. |
| 34% | JENWELTER | 9 | Veteran women's football player who recently became the NFL's first female coach: 2 wds. |
| 34% | LIUCIXIN | 8 | Author who, in 2015, became the first Asian to win the Hugo Award for Best Novel, for “The Three-Body Problem” |
| 34% | OCTAVIAN | 8 | General who became the first emperor of Rome |
| 34% | MELINA | 6 | Widely known Greek singer Mercouri, who, in 1981, became Greece's first female Minister for Culture and Sciences |
| 33% | ALBERTPUJOLS | 12 | St. Louis Cardinals first baseman who became the 32nd player to join the 3,000-hit club on 5/4/2018: 2 wds. |
| 33% | HERSCHEL | 8 | Caroline ___, German astronomer who was the first paid female scientist |
| 33% | SIANO | 5 | Nicky ___, DJ and music producer who was an integral part of New York's disco clubs in the 1970s |
| 33% | ONEIL | 5 | Buck who became the first African American coach in the MLB |
| 33% | RITA | 4 | Dove, who became the first African American U.S. Poet Laureate |
| 33% | MIGUELCABRERA | 13 | Detroit Tigers first baseman who became the 33rd (and most recent) player to join the 3,000-hit club on 4/23/2022: 2 wds. |
| 32% | ABLE | 4 | Monkey who became the first to return to Earth successfully in 1959 |
| 32% | SHIPBUILDER | 11 | Professional who uses the first words of the starred answers |
| 32% | RENO | 4 | Janet who was the first female attorney general |
| 32% | URSULA | 6 | ___ von der Leyen, first female head of the European Commission, who negotiated Brexit for the E.U. |
| 32% | CHLOEZHAO | 9 | 16-Across director who won an Academy Award for Best Director in 2021, becoming the first non-white woman to win a directing Oscar (2 wds.) |
| 32% | LAIKA | 5 | Dog who became the first living being to orbit the Earth in 1957 |
| 32% | VALENTINA | 9 | ___ Tereshkova, cosmonaut who became the first woman to fly in space in 1964 |
| 32% | RENO | 4 | Janet who was the first female US attorney general |
| 32% | INDIRA | 6 | Gandhi who was the first female PM of India |
| 32% | INDIRA | 6 | Gandhi who was the first female PM in India |
| 32% | EALA | 4 | Alexandra ___, tennis player who became the first Filipina to reach the WTA Top 100 |
| 32% | CZECH | 5 | Nationality of a poet and playwright who became the first president of his country |
| 32% | JAMES | 5 | LeBron ___, basketball player who became the first sophomore to be crowned "Ohio Mr. Basketball" |
| 32% | STEVEN | 6 | Yeun who was the first Asian American nominated for Best Actor (2020's "Minari") |
| 31% | ELSTON | 6 | Howard who became the Yankees’ first Black player, in 1955 |