| 100% | ALYN | 4 | Kirk ___, actor who was the first to play Superman |
| 73% | NIMOY | 5 | Actor Leonard who was the first to play Spock |
| 72% | ALEC | 4 | Actor Guinness who was the first to play Obi-Wan Kenobi |
| 71% | TOBEY | 5 | Actor Maguire who was the first to play Spider-Man in movies |
| 70% | IRA | 3 | Aldridge who was the first Black actor to play Othello |
| 70% | LORRE | 5 | Peter who was the first actor to play a Bond villain |
| 66% | DEE | 3 | Sandra who was the first to play "Gidget" |
| 66% | DEE | 3 | Actress Sandra who was the first to play Gidget |
| 66% | DEE | 3 | Actress Sandra who was the first to play "Gidget" |
| 66% | ALEC | 4 | Baldwin who was the first to play Jack Ryan |
| 64% | ALYN | 4 | Kirk ___, the first actor who played Superman |
| 63% | ANDREAMCARDLE | 13 | Tony-nominated actress who was the first to play 40-Across on Broadway (2 wds.) |
| 62% | ALYN | 4 | Kirk ___, first actor to play Superman on the big screen |
| 62% | BARRY | 5 | ___ Nelson, American actor who was the first to portray James Bond in a television series titled "Climax!" |
| 60% | REBA | 4 | Singer McEntire who was the first woman to play Colonel Sanders |
| 60% | ALI | 3 | Mahershala who was the first Muslim actor to win an Oscar |
| 59% | POITIER | 7 | Sidney who was the first African-American to win a Best Actor Oscar |
| 59% | POITIER | 7 | Sidney who was the first African American to win a Best Actor Oscar |
| 59% | ALYN | 4 | Kirk ___, the first actor to play Superman in live-action for the 1948 movie |
| 58% | MOORE | 5 | Roger who was the oldest actor to play James Bond |
| 58% | BENNYGOODMAN | 12 | Big Band bandleader who was the first jazz bandleader to play Carnegie Hall (2 wds.) |
| 58% | JACOBY | 6 | Ellsbury who was the first Native American of Navajo descent to play in Major League Baseball |
| 57% | BRYANT | 6 | Kobe ___, former Los Angeles Lakers player who was the first guard to play 20 seasons in NBA |
| 55% | CHUCKCONNORS | 12 | Actor who was one of only 13 athletes to play in both the NBA and the MLB (2 wds.) |
| 55% | ALYN | 4 | Kirk ___, first actor to play Superman |
| 54% | BIGMAMATHORNTON | 15 | Singer who was the first to record “Hound Dog” |
| 54% | ALYN | 4 | Kirk who played the first big-screen Superman |
| 54% | MELALLEN | 8 | Announcer who was the first to call DiMaggio "Joltin' Joe" |
| 53% | CHRISTIAN | 9 | Film actor Bale, who was the first Non-American to portray Batman/ Bruce Wayne |
| 53% | ALYN | 4 | Kirk ___, first actor to play Superman on screen, 1948 |