| 100% | ITASCA | 6 | Lake —, source in Minnesota, US, of the Mississippi River |
| 73% | ITASCA | 6 | Minnesota lake at the source of the Mississippi River |
| 69% | ITASCA | 6 | Minnesota lake that's the source of the Mississippi River |
| 61% | DULUTH | 6 | Port in Minnesota, US, at the west end of Lake Superior |
| 59% | ITASCA | 6 | Minnesota lake that's the headwater of the Mississippi River |
| 54% | ITASCA | 6 | Lake source of the Mississippi |
| 53% | STLOUIS | 7 | Port on the Mississippi River; largest city in Missouri, US |
| 52% | OSAGE | 5 | — River, tributary of the Missouri River in the US that flows into the Lake of the Ozarks reservoir |
| 52% | ERIE | 4 | Lake source of the Niagara River |
| 51% | ITASCA | 6 | Lake ___, source of the Mississippi |
| 50% | SHIRE | 5 | River in Africa; the only outlet of Lake Malawi |
| 50% | ILIAMNA | 7 | — Lake, largest in the US state of Alaska |
| 50% | STLOUIS | 7 | US port on the Mississippi River; largest city in Missouri |
| 49% | IRE | 3 | Source of much U.S. immigration in the 1840s: Abbr. |
| 49% | ERIE | 4 | Lake ___, source of the Niagara River |
| 49% | ERIE | 4 | Lake that's the source of the Niagara River |
| 49% | XXXX | 4 | Lake that's the source of the Niagara River |
| 49% | SNAP | 4 | Largest source of food benefits in the U.S. |
| 48% | ITASCA | 6 | Lake that's the source of the Mississippi |
| 48% | ITASCA | 6 | Lake that is a source of the Mississippi |
| 48% | ITASCA | 6 | Lake that's a source of the Mississippi |
| 48% | EDEN | 4 | Source of four great rivers, in the Bible |
| 48% | BUFFALO | 7 | US port in New York State at the eastern end of Lake Erie |
| 48% | GATEWAYARCH | 11 | Monument on the Mississippi River in St. Louis that appears on the collectible quarter of the 43-Across (2 wds.) |
| 47% | YAZOO | 5 | River in Mississippi, US, formed by the confluence of the Tallahatchie and Yalobusha Rivers |
| 47% | WINNEBAGO | 9 | Lake —, body of water in Wisconsin, US drained by the Fox River |
| 47% | OREGON | 6 | Home to the deepest lake and river gorge in the U.S. |
| 47% | ACADIA | 6 | Oldest national park east of the Mississippi River |
| 47% | MOHAWK | 6 | Largest tributary of the Hudson River in the state of New York, US |