| 100% | ISLEROYALE | 10 | Lake Superior locale that's the subject of a more than 60 year study of a unique moose-wolf relationship |
| 31% | REM | 3 | Sleep phase that might be the subject of a sleep study: Abbr. |
| 30% | NOUN | 4 | Part of speech that's the subject of a sentence, typically |
| 30% | SPAM | 4 | Food that's the subject of a museum in Austin, Minn. |
| 30% | AMBERGRIS | 9 | Secretion that's the subject of a chapter in Moby-Dick |
| 30% | LYNDON | 6 | Johnson that's the subject of a museum at the University of Texas |
| 30% | ELAND | 5 | African antelope that's the size of a moose |
| 30% | ANT | 3 | Bug that the more than 1 million members of a certain Facebook group pretend to be |
| 29% | BLT | 3 | Sandwich that's the subject of a "Manifesto" by J. Kenji López-Alt, for short |
| 28% | IRS | 3 | Agency that's the subject of the book "Confessions of a Tax Collector": Abbr. |
| 28% | DEAD | 4 | With 8-Across, subject of a theory that claims that most of the activity on social media is generated by bots |
| 28% | ENO | 3 | Brian who's the subject of a documentary that's different every time it's screened |
| 28% | CIA | 3 | Grp. that was the subject of a recent WikiLeaks release |
| 28% | XIII | 4 | Apollo mission that was the subject of a 1995 film |
| 28% | ITASCA | 6 | Lake that's a source of the Mississippi |
| 27% | NOUN | 4 | Part of speech that's typically the subject of a sentence |
| 27% | GTO | 3 | Car that was the subject of a 1964 top 10 hit |
| 27% | AOL | 3 | Tech company that was the subject of a 1997 Time cover |
| 27% | ANGORAS | 7 | Wool sources that were the subject of a 2013 PETA exposé |
| 27% | EMI | 3 | Co. that was the subject of a Sex Pistols diss track |
| 27% | RYU | 3 | Main character in Capcom's Street Fighter series whose "special move" was the subject of a scientific work last year |
| 27% | SILICON | 7 | More than a quarter of the earth's crust |
| 27% | NCAA | 4 | Org. that was the subject of a 2021 Supreme Court antitrust ruling |
| 27% | AFRICA | 6 | Continent with Nigeria that is the subject of a song by Toto |
| 27% | MATH | 4 | Subject that requires the use of a calculator, for short |
| 27% | GST | 3 | Facility for studies of the Sun with a 1.7 meter mirror, that's located on the north shore of California's Big Near Lake (abbr.) |
| 27% | SILICON | 7 | More than a quarter of the earth's crust, by mass |
| 27% | ERIE | 4 | Lake that was the site of a War of 1812 battle |
| 26% | NAL | 3 | Imprint of Penguin Random House that published "Ideal" in 2015, the first Ayn Rand novel to appear in more than fifty years (abbr.) |
| 26% | HYPERNOVA | 9 | Explosion of a star that's more than just "super" |