| 100% | COEN | 4 | Last name of the brothers who directed "O Brother, Where Art Thou?" |
| 53% | TBONE | 5 | Burnett who won four Grammys for the "O Brother, Where Art Thou?" soundtrack: 2 wds. |
| 52% | COEN | 4 | Last name of the filmmaking brothers who made "Raising Arizona" and "Fargo" |
| 50% | HOLLYHUNTER | 11 | "The Piano" actress who played Penny in "O Brother, Where Art Thou?": 2 wds. |
| 50% | JOHNGOODMAN | 11 | "The Conners" actor who played Big Dan in "O Brother, Where Art Thou?": 2 wds. |
| 48% | KLAN | 4 | Kind of meeting in "O Brother, Where Art Thou?" |
| 48% | GIBB | 4 | Last name of the brothers in 33a |
| 48% | AMA | 3 | “I ___ Man of Constant Sorrow” (song in “O Brother, Where Art Thou?”) |
| 47% | ALDA | 4 | Last name of the actor who played Hawkeye |
| 47% | GIBB | 4 | Last name of the brothers in the 19-Across |
| 47% | AMA | 3 | "I ___ Man of Constant Sorrow" (song in "O Brother, Where Art Thou?"): 2 wds. |
| 47% | GRANDE | 6 | Last name of the artist who sings Thank U, Next |
| 47% | ALI | 3 | Last name of the boxer who was born Cassius Clay |
| 46% | AMES | 4 | Last name of the "Rag Mop" singing brothers |
| 46% | JOELCOEN | 8 | Elder of the brothers who directed Fargo film |
| 46% | GIBB | 4 | Last name of the Bee Gees brothers |
| 45% | GEORGECLOONEY | 13 | "Ocean's Eleven" actor who played Everett in "O Brother, Where Art Thou?": 2 wds. |
| 45% | AMA | 3 | "I ___ Man of Constant Sorrow" ("O Brother, Where Art Thou?" song): 2 wds. |
| 45% | WARHOL | 6 | Last name of the pioneer artist of Pop Art |
| 45% | RADCLIFFE | 9 | Last name of the actor who was the titular protagonist in "Harry Potter" series |
| 45% | ALDA | 4 | Last name of the actor who played Hawkeye Pierce on "M*A*S*H" |
| 44% | NEILL | 5 | Last name of the "Jurassic Park" star who cameoed in "Thor: Ragnarok" |
| 44% | COEN | 4 | Either brother who co-wrote "O Brother, Where Art Thou?" |
| 43% | ARI | 3 | The name of the one who’s gonna last, in “Thank U, Next” |
| 43% | ALOU | 4 | Last name of the only MLB brother trio to play together in the outfield |
| 42% | HOMEALONE | 9 | "O Brother, Where Art Thou?" [1990] |
| 42% | DUFFER | 6 | Last name of brothers Matt and Ross who co-created "Stranger Things" |
| 41% | FDR | 3 | Initials of the president who had the same last name as Teddy |
| 40% | EARP | 4 | Last name of lawmen Wyatt and Virgil in the gunfight at the O.K. Corral |
| 40% | CURIE | 5 | Last name of the first woman to win the Nobel Prize and who is credited with the theory of radioactivity |