| 100% | OMAREPPS | 8 | Lead actor on "Resurrection": 2 wds. |
| 63% | TOMCRUISE | 9 | Lead actor of 2017's "The Mummy": 2 wds. |
| 62% | ELLIOTPAGE | 10 | Transgender actor on "The Umbrella Academy": 2 wds. |
| 60% | JOEYTRIBBIANI | 13 | Struggling actor on "Friends" played by Matt LeBlanc: 2 wds. |
| 59% | CHANNINGTATUM | 13 | Lead actor of 27-/28-Across, also known for "Magic Mike": 2 wds. |
| 59% | ORA | 3 | Outstanding Lead Actor in a Miniseries ___ Movie (Emmy category): 2 wds. |
| 59% | MRT | 3 | Bodyguard who become an actor on "The A-Team": 2 wds. |
| 58% | WILLSMITH | 9 | Lead actor and main character of "The Fresh Prince of Bel-Air": 2 wds. |
| 57% | DONALDGLOVER | 12 | Emmy winner for Outstanding Lead Actor in a Comedy for "Atlanta": 2 wds. |
| 57% | BOBODENKIRK | 11 | "Breaking Bad" actor who plays the lead role on 33-Across: 2 wds. |
| 57% | JUDDHIRSCH | 10 | 1981 Emmy winner for "Taxi" (Outstanding Lead Actor In a Comedy Series): 2 wds. |
| 56% | GLADYSKNIGHT | 12 | Lead singer on the 1970s hit "Midnight Train to Georgia": 2 wds. |
| 56% | ERICMCCORMACK | 13 | 2001 Emmy winner, Outstanding Lead Actor in a Comedy Series (for "Will & Grace"): 2 wds. |
| 55% | KITHARINGTON | 12 | "Pompeii" lead actor, who plays the role of Jon Snow in "Game Of Thrones" : 2 wds. |
| 55% | HOWIEMANDEL | 11 | He was an actor on "St. Elsewhere" before he hosted "Deal or No Deal": 2 wds. |
| 55% | ALANCUMMING | 11 | Scottish-born actor on "The Good Wife" who became a US citizen in 2008: 2 wds. |
| 55% | KEVINKLINE | 10 | 1981 Tony winner for "The Pirates of Penzance" (Best Leading Actor in a Musical): 2 wds. |
| 54% | BRYANCRANSTON | 13 | Lead actor in "Breaking Bad," who directed the episode "Blood Money" in the show's 5th season: 2 wds. |
| 54% | DAMIANLEWIS | 11 | Winner of the 2012 Emmy for Outstanding Lead Actor in a Drama Series for "Homeland": 2 wds. |
| 54% | JEREMYSTRONG | 12 | "Succession" star who won the 2020 Emmy for Outstanding Lead Actor in a Drama Series: 2 wds. |
| 54% | EUGENELEVY | 10 | Former SCTV regular who won the 2020 Emmy Award for Outstanding Lead Actor in a Comedy Series for playing Johnny Rose on 46-Across (2 wds.) |
| 54% | DREWSTARKEY | 11 | "Scream: Resurrection" actor who plays Rafe Cameron on "Outer Banks" (2 wds.) |
| 53% | WILLIAMSHATNER | 14 | "Star Trek" star who played a murderous actor on "Columbo": 2 wds. |
| 53% | JEFFDANIELS | 11 | Winner of the 2013 Emmy for Outstanding Lead Actor in a Drama Series for "The Newsroom": 2 wds. |
| 53% | BRYANCRANSTON | 13 | Winner of the 2014 Emmy for Outstanding Lead Actor in a Drama Series for "Breaking Bad": 2 wds. |
| 53% | LAURAINGALLS | 12 | Lead character on TV's "Little House on the Prairie," played by Melissa Gilbert: 2 wds. |
| 52% | EUGENELEVY | 10 | "Schitt's Creek" star who won the 2020 Emmy for Outstanding Lead Actor in a Comedy Series: 2 wds. |
| 51% | JOHNLITHGOW | 11 | 1996, 1997, and 1999 Emmy winner, Outstanding Lead Actor in a Comedy Series (for "3rd Rock From the Sun"): 2 wds. |
| 50% | NYAMBINYAMBI | 12 | "Mike & Molly" actor who plays lead investigator Jay DiPersia on 43-Across (2 wds.) |
| 50% | ANGELSIN | 8 | "___ America," 2003 miniseries starring Al Pacino for which he won an Emmy for Outstanding Lead Actor in a Limited Series: 2 wds. |