| 100% | BETSYROSS | 9 | Legendary creator of the first American flag |
| 81% | BETSY | 5 | Creator of the first American Flag, first name |
| 55% | ARTHURWYNNE | 11 | Creator of the first crossword |
| 54% | RCA | 3 | Creator of the first radio network |
| 53% | ATHENA | 6 | Mythical creator of the first spider |
| 52% | ASTOR | 5 | Family name of the first American multimillionaire |
| 50% | BETSY | 5 | Ross who is credited with creating the first American flag |
| 48% | CLARKSON | 8 | The first winner of American Idol, Kelly __ |
| 47% | AVA | 3 | ___ DuVernay, creator of the American drama TV series "Queen Sugar" |
| 47% | ARLINGTON | 9 | Site of the first Six Flags theme park |
| 47% | AMY | 3 | __ Beach, composer of the first symphony composed by an American woman |
| 47% | GISH | 4 | Lillian ___, the First Lady of American Cinema |
| 47% | BEN | 3 | Nickname of the so-called First American |
| 45% | CLARKSON | 8 | Kelly, who won the first series of American Idol |
| 45% | LILLIAN | 7 | Actress Gish nicknamed the First Lady of American Cinema |
| 45% | STARS | 5 | The American flag has fifty of them |
| 44% | SETHMACFARLANE | 14 | Creator of the American animated sitcom "Family Guy" who also voices other characters of the show: 2 wds. |
| 44% | STANTON | 7 | First president of the National American Woman Suffrage Association |
| 43% | EMIL | 4 | Comedian Wakim who is the first Lebanese American cast member of "SNL" |
| 43% | STARS | 5 | The American and Chinese flags have 55 of them, collectively |
| 43% | ASA | 3 | ___ Philip Randolph, civil rights activist and founder of the first AFL-chartered African American-led labor union |
| 43% | GERE | 4 | Richard who was the first man featured on the cover of American Vogue |
| 42% | REDSOX | 6 | Winner of the first World Series (as the "Americans") |
| 42% | BALBOA | 6 | Explorer who founded the first permanent European settlement on the mainland of the Americans |
| 42% | BULLRUN | 7 | First major battle of the American Civil War |
| 42% | VIOLA | 5 | Actress Davis who was the first African American to win the Triple Crown of Acting |
| 41% | CAPP | 4 | Creator of the Shmoos |
| 41% | HGWELLS | 7 | Creator of the Morlocks |
| 41% | POE | 3 | Creator of the Ushers |
| 41% | STEINBECK | 9 | Creator of the Joads |