| 100% | HIPAA | 5 | Legislation affecting medical care often named after Ted Kennedy and Nancy Kassebaum, signed by Pres. Clinton in '96 |
| 23% | PARTD | 5 | Medicare prescription drug benefit, proposed by Pres. Clinton in 1999 and signed by Pres. Bush in 2003, is also known as this |
| 22% | CAPTAIN | 7 | & 15A 1922 Derby-winning horse named after a character in Dombey and Son by Charles Dickens |
| 22% | DMASS | 5 | Abbr. after Ted Kennedy's name |
| 21% | CEMENT | 6 | Product heavily used today named after Portland, UK and patented by Joseph Aspdin in 1824 |
| 21% | TOPEKANS | 8 | Gwendolyn Brooks and Nancy Kassebaum, by birth |
| 20% | COSMOPOLITAN | 12 | Fashion magazine for women that has been in publication since 1886, and is often referred to by its shorter name |
| 19% | MOPTOP | 6 | Hairstyle named after and made popular by The Beatles: Hyph. |
| 19% | LOREAL | 6 | Big name in cosmetics and hair care |
| 19% | ORTHO | 5 | Big name in lawn and garden care |
| 19% | TUXEDO | 6 | Dinner jacket named after — Park, a village and resort in New York |
| 19% | SALTII | 6 | Nuclear-weapons agreement signed by Jimmy Carter and Leonid Brezhnev, in 1979 |
| 19% | MENOT | 5 | Words after touch and forget in flower names |
| 18% | WONKA | 5 | ___ Bar, fictional chocolate named after a character in "Charlie and the Chocolate Factory" |
| 18% | HERS | 4 | Big name in women's hair and skin care |
| 18% | OSHA | 4 | Labor law signed by Pres. Nixon in 1970 that astronauts in space are effectively exempt from |
| 18% | RIOT | 4 | Word after "Quiet" and "Pussy," in band names |
| 18% | BOYS | 4 | Word after "Beach" and "Backstreet," in band names |
| 18% | MAN | 3 | Word after "Spider" and "Ant" in superhero names |
| 18% | ERIN | 4 | Place name before and after "Oh" in a Thomas Moore title |
| 18% | SOX | 3 | Word after "Red" and "White" in baseball team names |
| 18% | TECH | 4 | Word after "Georgia," "Virginia," and "Texas" in university names |
| 17% | AVA | 3 | Third-most-popular baby girls' name in 2020, after Olivia and Emma |
| 17% | PEA | 3 | Word that goes before "nut" and after "chick" in two legume names |
| 17% | OPEN | 4 | Word after "Australian," "French," and "US" in tennis tournament names |
| 17% | ILOG | 4 | Municipality surrounded by the Hilabangan River and named after the Tagalog word for river in the Philippines |
| 17% | RIO | 3 | Character from "Money Heist" that is named after a Brazilian city and is played by Miguel Herran |
| 17% | BERLIN | 6 | Character from "Money Heist" that is named after a German city and is played by Pedro Alonso |
| 17% | NAIROBI | 7 | Character from "Money Heist" that is named after a Kenyan city and is played by Alba Flores |
| 17% | TOKYO | 5 | Character from "Money Heist" that is named after a Japanese city and is played by Ursula Corbero |