| 100% | YESNO | 5 | Like the questions asked in 20 Questions |
| 76% | YESNO | 5 | Like the questions asked in Guess Who? |
| 71% | YESNO | 5 | Like the questions in 20 Questions |
| 63% | WHATSSOFUNNY | 12 | Question asked in response to the starts of both words in 20-, 28- and 48-Across |
| 60% | YESNO | 5 | Like questions asked in Twenty Questions: Hyph. |
| 59% | YESNO | 5 | Like questions in 20 Questions |
| 59% | GUESSES | 7 | The 20 in 20 Questions |
| 57% | YESNO | 5 | Like the questions in Twenty Questions: Hyph. |
| 55% | ONEWORD | 7 | Like the responses in Twenty Questions |
| 54% | YES | 3 | One of the two possible answers in 20 Questions |
| 54% | AMILATE | 7 | Question asked while running in the door |
| 51% | YES | 3 | One of the answers in a 20 Questions game |
| 50% | SHARKINFESTED | 13 | Like the waters in 1 Across...and 20, 28, and 45 Across? |
| 50% | PIANOROLLS | 10 | Cylinders like the 20,000+ housed in London's Musical Museum |
| 47% | HOW | 3 | Question asked in befuddlement |
| 46% | TENNISANYONE | 12 | Question you might feel like asking after seeing nine key words in this puzzle? |
| 46% | WHY | 3 | Question I often ask myself when working on puzzles at three in the morning |
| 45% | WHEREAMI | 8 | Question asked in a foggy state |
| 45% | ISITI | 5 | Question asked in Matthew 26:22 |
| 45% | ISITLIVE | 8 | Question asked in classic 1970s ads |
| 45% | RIDDLER | 7 | The questioning villain in Batman comics |
| 45% | ACEHIGH | 7 | Like the best straight in poker |
| 45% | COMMON | 6 | Like the name Nguyen in Vietnam |
| 45% | ONGOAL | 6 | Like the best shots in hockey |
| 45% | ACTIVE | 6 | Like the ingredient acetaminophen in Tylenol |
| 45% | ARTSY | 5 | Like the Chelsea neighborhood in Manhattan |
| 45% | SOFT | 4 | Like the G's in gingerbread |
| 45% | SAHARAN | 7 | Like the largest desert in Africa |
| 45% | GORY | 4 | Like the movie mentioned in 30a |
| 45% | ARID | 4 | Like the central planet in "Dune" |