| 100% | BARRYSANDERS | 12 | Lions running back who's #3 in NFL career rushing yards: 2 wds. |
| 82% | CURTISMARTIN | 12 | Patriots/Jets running back who's #4 in NFL career rushing yards: 2 wds. |
| 75% | WALTERPAYTON | 12 | Bears running back who's #2 in NFL career rushing yards, behind Emmitt Smith: 2 wds. |
| 55% | ADRIANPETERSON | 14 | Vikings running back who gained 296 total yards in a 2007 NFL game, the most ever: 2 wds. |
| 54% | JEROMEHARRISON | 14 | Browns running back who gained 286 total yards in a 2009 NFL game, the third-most ever: 2 wds. |
| 49% | KEVINGREENE | 11 | Rams/Steelers/Panthers/49ers linebacker who's #3 in NFL career sacks with 160: 2 wds. |
| 48% | ERIC | 4 | Running back Dickerson who holds the NFL record for most rushing yards in a playoff game |
| 44% | REGGIEBUSH | 10 | Saints running back who explained "appetite" on "Sesame Street" in 2010: 2 wds. |
| 44% | TIKIBARBER | 10 | Giants running back who explained "quest" on "Sesame Street" in 2009: 2 wds. |
| 43% | BARRYSANDERS | 12 | Former NFL running back who shared the AP NFL Most Valuable Player Award with Brett Favre in 1997: 2 wds. |
| 43% | EDGERRINJAMES | 13 | Indianapolis Colts running back with 12,246 career rushing yards elected to the Pro Football Hall of Fame in 2020 (2 wds.) |
| 42% | WALTERPAYTON | 12 | Longtime Chicago Bears running back who sang in his high school choir: 2 wds. |
| 42% | BARRYSANDERS | 12 | Hall of Fame Detroit Lions running back on 2014's "Madden NFL 25" cover: 2 wds. |
| 41% | BLAKECORUM | 10 | 30-Across/48-Across running back who led all rushers with 134 yards and two touchdowns in the 2024 College Football Playoff National Championship (2 wds.) |
| 41% | JIMBROWN | 8 | Record-setting 1950s-1960s running back who was an All-American in lacrosse at Syracuse University: 2 wds. |
| 40% | MARSHAWNLYNCH | 13 | "Beast Mode" running back who came out of retirement in 2017 to play for the Oakland Raiders: 2 wds. |
| 40% | JAMAL | 5 | With 40-Across, Ravens running back who gained 295 total yards in a 2003 NFL game, the second-most ever |
| 38% | REGGIEWHITE | 11 | Eagles/Packers/Panthers defensive end who's #2 in NFL career sacks with 198: 2 wds. |
| 38% | DONOVAN | 7 | With 40-Across, 30-Across/48-Across running back who rushed for 104 yards and two touchdowns in the 2024 College Football Playoff National Championship |
| 38% | TIKIBARBER | 10 | NFL running back who played alongside his twin brother, Ronde, at the University of Virginia and on three Pro Bowl teams: 2 wds. |
| 36% | EDMARINARO | 10 | Former NFL running back who played a police officer on "Hill Street Blues" (2 wds.) |
| 35% | JIMBROWN | 8 | Real-life NFL running back portrayed by Aldis Hodge in "One Night in Miami": 2 wds. |
| 35% | CAM | 3 | Newton who is the NFL's all-time leader in career quarterback rushing touchdowns |
| 35% | TIKIBARBER | 10 | Onetime New York Giants running back who also cuts men's hair?: 2 wds. |
| 34% | MARKINGRAMJR | 12 | Texans running back who won the 2009 Heisman Trophy as a sophomore at Alabama: 3 wds. |
| 34% | DERRICKHENRY | 12 | Titans running back who won the 2015 Heisman Trophy as a junior at Alabama: 2 wds. |
| 34% | AARON | 5 | Hank who's #2 in career home runs |
| 34% | BLUEIVYCARTER | 13 | Beyoncé's daughter who voices Simba and Nala's cub Kiara in "Mufasa: The Lion King": 3 wds. |
| 33% | BOJACKSON | 9 | Los Angeles Raiders running back who played Major League Baseball for the Royals, White Sox, and Angels: 2 wds. |
| 33% | YDS | 3 | Running back's stat in the NFL: Abbr. |