| 100% | LING | 4 | Lisa who hosts CNN's "This Is Life" |
| 66% | LING | 4 | CNN's "This Is Life with Lisa ___" |
| 66% | LING | 4 | CNN's "This Is Life With Lisa __" |
| 58% | LING | 4 | "This Is Life" host Lisa |
| 48% | IRA | 3 | Glass who hosts NPR's "This American Life" |
| 48% | ERIN | 4 | Burnett who hosts CNN’s “OutFront” |
| 47% | LING | 4 | “This Is Life” journalist Lisa |
| 45% | ROWE | 4 | Mike who hosts CNN's "Somebody's Gotta Do It" |
| 45% | LISA | 4 | Journalist Ling, host of CNN's documentary series "This Is Life" |
| 44% | IRA | 3 | Glass who hosts public radio's "This American Life" |
| 44% | GLASS | 5 | Ira who hosts public radio's "This American Life" |
| 44% | IRA | 3 | Glass who hosts "This American Life" |
| 43% | ANDERSONCOOPER | 14 | "360°" CNN host who is a correspondent for "60 Minutes": 2 wds. |
| 43% | SAJAK | 5 | Game show host Pat who was nominated for two Emmys this year |
| 42% | IRA | 3 | Glass who hosts "This American Life" on NPR |
| 42% | BONET | 5 | Actress Lisa who is Zöe Kravitz’s mother |
| 42% | IRA | 3 | Glass who hosts the radio show "This American Life" |
| 41% | IRA | 3 | Glass who hosts the public radio show "This American Life" |
| 41% | IRA | 3 | Glass who hosts the "This American Life" radio show/podcast |
| 41% | TESH | 4 | John who hosts radio's "Intelligence for Your Life" |
| 41% | ANDERSONCOOPER | 14 | CNN host who was honored with the 2018 Walter Cronkite Award for Excellence in Journalism (2 wds.) |
| 41% | BIO | 3 | This is your life |
| 40% | GETUSEDTOIT | 11 | "Better adapt, because this is life now!" |
| 40% | MYSELF | 6 | This is who I am |
| 39% | ALEX | 4 | Trebek who once hosted this puzzle's theme |
| 39% | LISA | 4 | "This Is Life With ___ Ling" (CNN series) |
| 39% | LOTUSPOSE | 9 | One who's meditating might be in this |
| 39% | THEFRIENDSWEMADEALONG | 21 | With 126/127 Across, companions on our life's journey who were more valuable to us than our destination ... and an alternate title for this puzzle |
| 39% | MONA | 4 | Lisa who lives at the Louvre |
| 39% | IKNOWAGUY | 9 | “There’s this fellow who might be able to help you” |