| 100% | HEIDI | 5 | Literary heroine whose best friend is a goatherd |
| 57% | DORA | 4 | Cartoon explorer whose best friend is a monkey named Boots |
| 54% | ELMO | 4 | Red Muppet on "Sesame Street" whose best friend is a pink fairy named Abby Cadabby |
| 53% | PRINCESSMERIDA | 14 | Disney cartoon character with red hair whose best friend is a horse named Angus (2 wds.) |
| 51% | GEORGE | 6 | With 35-Across, Hanna-Barbera cartoon character with red hair whose best friend is a supercomputer named R.U.D.I. |
| 47% | FRODO | 5 | Hobbit whose best friend is Sam |
| 47% | KEN | 3 | Doll whose best friend is Allan |
| 46% | NAPOLEON | 8 | Dynamite character whose best friend is Pedro |
| 46% | DORA | 4 | Cartoon explorer whose best friend is Boots |
| 46% | DORA | 4 | Cartoon girl whose best friend is Boots |
| 45% | DORATHEEXPLORER | 15 | Animated TV character whose best friend is Boots |
| 45% | YOGI | 4 | Animated bear whose best friend is Boo-Boo |
| 43% | SPONGEBOB | 9 | First name of the cartoon character whose best friend is Patrick Star |
| 42% | CHUCKIEFINSTER | 14 | Nickelodeon cartoon character with red hair whose best friend is Tommy Pickles (2 wds.) |
| 41% | LISTENS | 7 | Is a good friend, in a way |
| 40% | STYNE | 5 | "Diamonds Are a Girl's Best Friend" composer |
| 40% | DIAMONDS | 8 | These gemstones are a girl's best friend |
| 40% | DIAMONDS | 8 | Gems that are a girl's best friend |
| 40% | DIAMONDS | 8 | Precious gems that are a girl's best friend? |
| 40% | MONROE | 6 | "Diamonds Are a Girl's Best Friend" singer Marilyn |
| 40% | BULLFROG | 8 | Jeremiah was a ___, was a good friend of mine |
| 39% | MANS | 4 | A dog is a ___ best friend |
| 39% | AUNTEM | 6 | Literary character whose house is uprooted by a tornado |
| 39% | AHAB | 4 | Literary captain whose name is a byword for obsession |
| 38% | FLEDGLING | 9 | A baby bird whose wings are good enough for flight |
| 37% | POE | 3 | Literary figure whose name is a letter short of something he wrote |
| 36% | DONALD | 6 | Mickey Mouse's duck best friend who is always seen wearing a sailor shirt and cap |
| 36% | CAMERA | 6 | I am a photographer's best friend. I help them capture every memory. Who am I? |
| 36% | GIRLS | 5 | "Diamonds Are a ___ Best Friend," song performed by Marilyn Monroe in 1953's "Gentlemen Prefer Blondes" |
| 36% | CHANDLER | 8 | Friends character whose surname is a cherry |