| 100% | MARTHA | 6 | Little ___, rabbit who was the first of her kind to be launched into space in 1959 |
| 41% | ALEKSEI | 7 | Leonov who was the first man to walk in space |
| 41% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 39% | JACOBY | 6 | Ellsbury who was the first Native American of Navajo descent to play in Major League Baseball |
| 39% | YURIGAGARIN | 11 | Russian who was the first person to travel into space and orbit the earth (1961): 2 wds. |
| 38% | LISALESLIE | 10 | Basketball Hall of Fame inductee who was the first player to dunk in a WNBA game: 2 wds. |
| 38% | ETHELWATERS | 11 | Harlem Renaissance singer and actress who was the first African American to star in her own TV show: 2 wds. |
| 37% | JACKIESTILES | 12 | 2016 Women's Basketball Hall of Fame inductee who was the first Division I player to score over 1,000 points in a season: 2 wds. |
| 37% | SARAHPALIN | 10 | In 2006, she became the first woman to be elected governor of Alaska: 2 wds. |
| 37% | SUSANAMARTINEZ | 14 | In 2010, she became the first woman to be elected governor of New Mexico: 2 wds. |
| 37% | NIKKIHALEY | 10 | In 2010, she became the first woman to be elected governor of South Carolina: 2 wds. |
| 36% | TROYAIKMAN | 10 | NFL quarterback who was the first overall draft pick in 1989 and was inducted into the Pro Football Hall of Fame in 2006 (2 wds.) |
| 36% | TERRYBRADSHAW | 13 | NFL quarterback who was the first overall draft pick in 1970 and was inducted into the Pro Football Hall of Fame in 1989 (2 wds.) |
| 36% | ARTHURCCLARKE | 13 | "2001: A Space Odyssey" novelist who was inducted into the Science Fiction and Fantasy Hall of Fame in 1997 (3 wds.) |
| 36% | LAIKA | 5 | Dog who was the first animal in space |
| 36% | SHEPARD | 7 | Alan who was the first American in space |
| 36% | BRUCESMITH | 10 | NFL defensive end who was the first overall draft pick in 1985 and was inducted into the Pro Football Hall of Fame in 2009 (2 wds.) |
| 36% | NEIL | 4 | First name in NASA's prestigious list of astronauts who have been to the moon |
| 36% | SUNILEE | 7 | Gymnast who was the first Hmong American athlete to compete in the Olympics |
| 36% | IVANI | 5 | Person who built the first stone Cathedral of the Archangel in Moscow and was also the first person to be buried there |
| 36% | YURI | 4 | Cosmonaut Gagarin who was the first person in space |
| 36% | ALAN | 4 | Astronaut Shepard who was the first American in space |
| 36% | MAE | 3 | Jemison who was the first Black woman in space |
| 36% | JEMISON | 7 | Mae who was the first Black woman in space |
| 36% | SALLY | 5 | ___ Ride who was the first American woman in space |
| 36% | YURI | 4 | Gagarin who was the first human in outer space |
| 36% | OCHOA | 5 | Astronaut Ellen who was the first Latina in space |
| 36% | ELLEN | 5 | Astronaut Ochoa who was the first Latina in space |
| 36% | LUCILLEBALL | 11 | Sitcom pioneer who was in the first class of inductees into the Television Hall of Fame (2 wds.) |
| 36% | BUCKONEIL | 9 | Negro League great who was the first African-American coach in the MLB and who was inducted into the Baseball Hall of Fame in 2022 (2 wds.) |