| 100% | TYLERPERRY | 10 | Madea portrayer hosting and narrating 42-Across: 2 wds. |
| 46% | TONYCURTIS | 10 | Portrayer of Joe and Josephine in 42-Across: 2 wds. |
| 46% | JACKLEMMON | 10 | Portrayer of Jerry and Daphne in 42-Across: 2 wds. |
| 45% | KALEYCUOCO | 10 | Portrayer of Penny on 42-Across: 2 wds. |
| 39% | JOHNNYGALECKI | 13 | Portrayer of Leonard Hofstadter on 42-Across: 2 wds. |
| 39% | JIMPARSONS | 10 | Portrayer of Sheldon Cooper on 42-Across: 2 wds. |
| 39% | MARILYNMONROE | 13 | Portrayer of Sugar Kane in 42-Across: 2 wds. |
| 38% | DROZ | 4 | TV host and surgeon whose first name is Mehmet: 2 wds. |
| 37% | BRITNEYSPEARS | 13 | "Toxic" singer who hosted and performed on "SNL" in 2000 and 2002: 2 wds. |
| 37% | BRUNOMARS | 9 | "The Lazy Song" singer who hosted and performed on "SNL" in 2012: 2 wds. |
| 36% | ELTONJOHN | 9 | "Rocket Man" singer who hosted and performed on "Saturday Night Live" in 2011: 2 wds. |
| 36% | BLACKSWAN | 9 | Ballet film starring Natalie Portman and 42-Across (2 wds.) |
| 36% | BLOODTIES | 9 | Crime film starring Clive Owen and 42-Across (2 wds.) |
| 36% | CONANOBRIEN | 11 | Longtime late-night host and former "SNL" writer who returned to host in 2001: 2 wds. |
| 35% | FANTASYISLAND | 13 | Television drama series produced by 42-Across featuring Mr. Roarke and Tattoo (2 wds.) |
| 35% | JOHNNYCARSON | 12 | American talk show host and comedian who hosted "The Tonight Show" for three straight decades: 2 wds. |
| 35% | DANIELDERONDA | 13 | 1876 novel by 42-Across featuring the characters Hugo Mallinger and Gwendolen Harleth (2 wds.) |
| 34% | GOLDENSLAM | 10 | 42-Across's amazing 1988 feat (singles wins at the Olympics and all four tennis majors) (2 wds.) |
| 34% | ELLENDEGENERES | 14 | Talk show host and star of a 1990s ABC sitcom, whose title was her first name: 2 wds. |
| 34% | ARIANAGRANDE | 12 | "7 Rings" singer who was both the host and musical guest on a 2016 "SNL" episode: 2 wds. |
| 34% | NICKJONAS | 9 | "Jealous" pop singer who both hosted and was the musical act in a 2021 "SNL" episode: 2 wds. |
| 34% | BADBUNNY | 8 | "Moscow Mule" rapper who both hosted and was the musical act in a 2023 "SNL" episode: 2 wds. |
| 34% | SMOKEYROBINSON | 14 | 42-Across singer/songwriter who was inducted into the Rock and Roll Hall of Fame in 1987 (2 wds.) |
| 33% | MEGANTHEE | 9 | With 46-Across, "Savage" rapper who both hosted and was the musical act in a 2022 "SNL" episode: 2 wds. |
| 33% | BILLIEEILISH | 12 | "Bad Guy" singer who was both the host and musical guest on a 2021 "Saturday Night Live" episode: 2 wds. |
| 33% | PAIGEDAVIS | 10 | TV personality and actress who hosts 31-Across: 2 wds. |
| 32% | THEBEATLES | 10 | Group cofounded by 42-Across: 2 wds. |
| 32% | KONMARIMETHOD | 13 | System of 18-Across and tidying up developed by 42-Across (2 wds.) |
| 32% | BETTERNOW | 9 | 2018 Top 10 song by 42-Across (2 wds.) |
| 31% | JENNYLHOWE | 10 | Author of 14-Across and 42-Across (3 wds.) |