| 100% | PLOTARMOR | 9 | Main character’s protection from being killed off, facetiously |
| 55% | PLOTARMOR | 9 | Major character’s figurative protection from being killed |
| 38% | RICKRIORDAN | 11 | Best-selling author of fantasy novels whose main characters are descended from gods: 2 wds. |
| 35% | VEEP | 4 | Show whose main character's autobiography was titled A Woman First: First Woman |
| 35% | RIO | 3 | 2011 animated film whose main character is a Spix's macaw |
| 34% | ICHABOD | 7 | Main character from Sleepy Hollow, __ Crane |
| 34% | SAL | 3 | One the main character's from Jack Kerouac's "On the Road", not Dean Moriarty |
| 34% | ROXIEHART | 9 | Main character from Chicago played by Zellweger |
| 33% | ACTONE | 6 | When main characters are typically introduced |
| 32% | APRIL | 5 | ___ Ludgate, character from "Parks & Recreation", who is everyone's spirit animal |
| 32% | SACRIFICEMCFLY | 14 | Kill off a major "Back to the Future" character? |
| 32% | TOMBRAIDER | 10 | Franchise whose main character is Lara Croft |
| 32% | CSI | 3 | Show whose main character was Gil Grissom |
| 32% | PATENTED | 8 | Protected from being knocked off |
| 32% | FINCH | 5 | Scout ___, famous literary character from Harper Lee's "To Kill A Mockingbird" |
| 32% | COCO | 4 | 2017 film whose main character is Miguel Rivera |
| 32% | ELF | 3 | 2003 holiday movie whose main character is Buddy |
| 32% | ISH | 3 | "Grown-___" (sitcom whose main character is Zoey Johnson) |
| 32% | CARS | 4 | 2006 film whose main character is Lightning McQueen |
| 32% | EPISODEONE | 10 | The main characters are usually introduced in it |
| 32% | EVITA | 5 | Hit 1979 musical in which a character's mistress is one of the main roles |
| 31% | ELF | 3 | Holiday movie in which Will Ferrell's character journeys from the North Pole |
| 31% | RYU | 3 | Main character in Capcom's Street Fighter series whose "special move" was the subject of a scientific work last year |
| 31% | DECKER | 6 | Chloe ___, main character from the fantasy TV series "Lucifer" |
| 31% | APE | 3 | What the main character in "Mighty Joe Young" was |
| 31% | TORRANCE | 8 | Jack __, main character in S. King's The Shining |
| 31% | MOM | 3 | Sitcom whose main characters are Christy and Bonnie Plunkett |
| 31% | OSLO | 4 | 2017 Tony-winning play whose main characters are diplomats |
| 31% | TED | 3 | ___ Mosby, the main character from "How I Met Your Mother" |
| 31% | INCEPTION | 9 | 2010 sci-fi thriller with main characters who are "extractors" |