| 100% | ABBOTT | 6 | Margaret ___, golfer and the first American woman to win an Olympic event |
| 65% | RONDA | 5 | Rousey who was the first American woman to win an Olympic judo medal |
| 63% | LINDSEY | 7 | ___ Vonn, former alpine ski racer who was the first American woman to win an Olympic gold in downhill skiing |
| 57% | RONDA | 5 | Rousey, first American woman to win an Olympic medal in judo |
| 54% | RETTON | 6 | First American woman to win the all-around gold in Olympic gymnastics |
| 49% | THORPE | 6 | First Native American to win an Olympic gold medal for the United States |
| 47% | JANEADDAMS | 10 | Social worker who was the first American woman to win the Nobel Peace Prize |
| 47% | PEARLSBUCK | 10 | First American woman to win the Nobel Prize for Literature (3 wds.) |
| 47% | RETTON | 6 | First American woman to win all-around gymnastics gold at the Olympics |
| 47% | DAWES | 5 | American gymnast Dominique who was the first Black athlete to win an Olympic gold medal in gymnastics |
| 46% | FRANCESARNOLD | 13 | First American woman to win the Nobel Prize in Chemistry, in 2018: 2 wds. |
| 46% | PEARLSBUCK | 10 | First American woman to win the Nobel Prize in Literature, in 1938: 3 wds. |
| 46% | DANICAPATRICK | 13 | First woman to win an IndyCar event: 2 wds. |
| 44% | RUDOLPH | 7 | Wilma ___, late American sprinter who was the first American woman to win three gold medals in a single Olympic Games |
| 43% | SUNISALEE | 9 | First Hmong American to win an Olympic gold medal |
| 42% | EVELYNASHFORD | 13 | The first track and field athlete to run 100 meters under 11 seconds in an Olympic Games and who has won a total of 5 Olympic medals: 2 wds. |
| 42% | SALLYRIDE | 9 | The first American woman to travel to space |
| 40% | CLARESSASHIELDS | 15 | First American to win back-to-back Olympic gold medals in boxing, in 2012 and 2016 |
| 40% | DEBBIE | 6 | ___ Armstrong, former alpine skier who was the first female American skier to win an Olympic gold medal |
| 40% | WILMA | 5 | Considered the world's fastest woman in the 60s, she became the first American woman to win three golds in a single Olympic Games |
| 39% | HOWE | 4 | Julia ___, first woman elected to the American Academy of Arts and Letters |
| 39% | MIRAINAGASU | 11 | First American woman to land a triple axel at the Olympics |
| 39% | SIDNEY | 6 | Actor and director Poitier, the first black person to win an Oscar for best actor |
| 38% | JACKIE | 6 | Some call her the First Lady of American athletics and has won several Olympic medals in heptathlon and long jump |
| 38% | EDITH | 5 | ___ Wharton, "The Age of Innocence" novelist and the first woman to win the Pulitzer Prize in Literature |
| 38% | ROSE | 4 | ___ Zhang, first woman to win the NCAA D1 individual championship twice (2022 and 2023) |
| 38% | JANEADDAMS | 10 | First American woman to be awarded the Nobel Peace Prize, in 1931: 2 wds. |
| 38% | MORRISON | 8 | First Black woman to win the Nobel Prize in Literature |
| 37% | WANGARI | 7 | ___ Maathai, Kenyan activist and first African woman to win the Nobel Peace Prize |
| 37% | CURIE | 5 | First woman to win the Nobel Prize |