| 100% | CURIE | 5 | Marie who is the only person to win a Nobel Prize in two different science fields |
| 60% | CURIE | 5 | Only person to win a Nobel Prize in two scientific fields |
| 57% | MARIECURIE | 10 | Only person to win the Nobel Prize in two different scientific fields |
| 49% | MARIE | 5 | Curie who was the first person to win two Nobel Prizes |
| 43% | SUE | 3 | Bird who is the only player to win WNBA titles in three different decades |
| 42% | LINUS | 5 | Only Nobelist besides Marie to win the prize in two fields |
| 39% | KIMMULKEY | 9 | Coach of 41-Across who is the only coach in women's college basketball to win national championships with two teams (2 wds.) |
| 39% | YUTOHORIGOME | 12 | Japanese skateboarder who was the first person to win a gold medal in skateboarding at the Olympics, in men's street skateboarding in Tokyo in 2021 (2 wds.) |
| 39% | STEFFIGRAF | 10 | Tennis player who is the only player (man or woman) to win a Grand Slam and Olympic gold medal in one year: 2 wds. |
| 39% | NINA | 4 | García who is the only person to be a judge on every season of "Project Runway" |
| 39% | GRAPHICNOVEL | 12 | "Maus" is the only one to win a Pulitzer Prize (1992) |
| 38% | ROBERTFROST | 11 | 17-Across and 26-Across writer who is the only person to win four Pulitzer Prizes for Poetry (2 wds.) |
| 38% | LUISE | 5 | Rainer who was the first person to win two Academy Awards for acting |
| 38% | EDITH | 5 | Wharton who was the first woman to win a Pulitzer Prize for fiction |
| 37% | ANDRETTI | 8 | Only person to be named Driver of the Year in three different decades |
| 36% | SUE | 3 | Point guard Bird who is the only player to win WNBA titles in three decades |
| 36% | JANEADDAMS | 10 | Social worker who was the first American woman to win the Nobel Peace Prize |
| 36% | SUE | 3 | Bird who's the only player to win WNBA titles in three different decades |
| 36% | ELI | 3 | ___ Broad, American entrepreneur and philanthropist, who is the only individual to have created two Fortune 500 companies in different industries |
| 35% | MICHAEL | 7 | ___ Schumacher, retired German racer who is the only racer in history to win seven Formula One World Drivers' Championships |
| 35% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 35% | ISABELWILKERSON | 15 | "Caste" author who was the first Black woman to win the Pulitzer Prize in journalism |
| 35% | ANGELA | 6 | Bassett who was the first person to be nominated for an Oscar for acting in a Marvel movie |
| 35% | DIAMONDJIMBRADY | 15 | Tycoon who was the first person in New York City to own a car |
| 35% | GENE | 4 | Upshaw who is the only NFL player to go to the Super Bowl in three different decades with the same team |
| 35% | KIMMULKEY | 9 | Coach of the 40-Across who is the only coach in women's college basketball to win national championships with two teams (2 wds.) |
| 35% | ALTHEA | 6 | Gibson who was the first person of color to win a tennis Grand Slam event |
| 35% | JIMMYCONNORS | 12 | Tennis great who is the only player to win the US Open Men's Singles championship on three different surfaces (2 wds.) |
| 34% | TONI | 4 | First name of the first Black woman to win a Nobel Prize in Literature |
| 34% | TATUM | 5 | Actress O'Neal who was the youngest person to ever win a competitive Oscar, at age 10 |