| 100% | WASP | 4 | Marmon _____ (first auto to win the Indy 500) |
| 64% | DANICAPATRICK | 13 | First woman to lead the Indy 500: 2 wds. |
| 57% | MARIOANDRETTI | 13 | The only driver to win the Indy 500, Daytona 500, and Formula One World Championship: 2 wds. |
| 53% | LYN | 3 | ___ St. James, first woman to win the Indianapolis 500 Rookie of the Year (1992) |
| 52% | UNSER | 5 | Family that's won the Indy 500 nine times |
| 52% | CURIE | 5 | First woman to win the Nobel Prize |
| 51% | CURIE | 5 | First woman to win the Nobel Prize. Marie ___ |
| 51% | ZAHAHADID | 9 | First woman to win the Pritzker Architecture Prize |
| 51% | AJFOYT | 6 | Driver who won the Indy 500, Daytona 500 and Le Mans |
| 51% | DIOMED | 6 | First horse to win the Epsom Derby in 1780 |
| 50% | JOHNNYMANZIEL | 13 | First freshman to win the 15-Across, in 2012: 2 wds. |
| 49% | UNSER | 5 | Al ___, international hall of fame-inducted racer who won the Indy 500 multiple times. |
| 49% | ALFONSOCUARON | 13 | First Mexican to win the Best Director Oscar (for "Gravity"): 2 wds. |
| 47% | MASERATI | 8 | Car that won the 1939 and '40 Indy 500 |
| 46% | ALUNSER | 7 | Oldest driver to win the Indianapolis 500 (2 wds.) |
| 46% | CURIE | 5 | Marie ___, first woman to win the Nobel Prize |
| 46% | BERNIEPARENT | 12 | First player to win the NHL's Conn Smythe Trophy in consecutive years (1974, 1975) (2 wds.) |
| 45% | MICHELEBACHMANN | 15 | First female candidate to win the Ames Straw Poll |
| 45% | ASHE | 4 | First Black man to win the U.S. Open |
| 45% | AJFOYT | 6 | Only driver to win Indy and Le Mans in the same year |
| 44% | LEANNRIMES | 10 | First country singer to win the Best New Artist Grammy |
| 44% | ANG | 3 | ___ Lee, first Asian to win the Oscar for Best Director |
| 44% | BOB | 3 | ___ Dylan, first musician to win the Nobel Prize in Literature |
| 44% | ZAILAAVANTGARDE | 15 | First African American to win the Scripps National Spelling Bee |
| 44% | MORRISON | 8 | First Black woman to win the Nobel Prize in Literature |
| 44% | ALI | 3 | First heavyweight boxer to win the championship belt three times |
| 44% | OTT | 3 | First of the 49-Across to hit 500 home runs |
| 44% | EDITH | 5 | Wharton, the first woman to win a Pulitzer |
| 43% | RETTON | 6 | First American woman to win the all-around gold in Olympic gymnastics |
| 43% | PEARLSBUCK | 10 | First American woman to win the Nobel Prize for Literature (3 wds.) |