| 100% | DOUG | 4 | McKenzie brother played by Dave Thomas on "SCTV" |
| 46% | NILES | 5 | Crane brother played by David Hyde Pierce on "Frasier" |
| 45% | NILES | 5 | Crane brother played by David Hyde Pierce on 43-Across |
| 45% | ALAN | 4 | Brother played by Jon Cryer on "Two and a Half Men" |
| 44% | DEAN | 4 | Winchester brother played by Jensen Ackles on "Supernatural" |
| 42% | RICOTUBBS | 9 | Undercover detective played by Philip Michael Thomas on 52-Across (2 wds.) |
| 36% | GOB | 3 | "Arrested Development" brother played by Will Arnett |
| 36% | LITTLEJOE | 9 | "Bonanza" brother played by 49-Across (2 wds.) |
| 36% | EAR | 3 | Play by ___ (handle on the spot) |
| 35% | DRAX | 4 | The Guardian of the Galaxy played by Dave Bautista |
| 35% | MISSMARPLE | 10 | 1950s private detective in St. Mary Mead played by Geraldine McEwan and Julia McKenzie on a 2004-2013 British TV series (2 wds.) |
| 35% | RAFESADLER | 10 | Character played by actor Thomas Brodie-Sangster in the British television serial "Wolf Hall" based on Hilary Mantel novels: 2 wds. |
| 34% | RON | 3 | Weasley brother played by Rupert Grint in the Harry Potter films |
| 34% | CLEOPATRA | 9 | Foxxy __, character played by Beyonce on film |
| 34% | DRAX | 4 | ___ the Destroyer (alliterative “Guardians of the Galaxy” character played by Dave Bautista) |
| 33% | LESLIEABRAMSON | 14 | Defense attorney played by Edie Falco on an NBC true crime anthology series about the Menendez brothers (2 wds.) |
| 33% | JOHNLOCKE | 9 | Character played by Terry O'Quinn on Lost |
| 33% | DRUMS | 5 | Instrument played by Animal on "The Muppet Show" |
| 33% | DRUM | 4 | Instrument played by Animal on “The Muppet Show” |
| 33% | TICTACTOE | 9 | Game played by contestants on "Hollywood Squares": Hyph. |
| 33% | IRA | 3 | Gershwin brother played by Herbert Rudley in the 1945 movie "Rhapsody in Blue" |
| 33% | ANNIE | 5 | Title character played by Sarah Jessica Parker on Broadway |
| 33% | OBOE | 4 | Woodwind played by Hailey on "Mozart in the Jungle" |
| 33% | OMAR | 4 | Character played by Michael K. Williams on “The Wire” |
| 33% | TISH | 4 | Character played by Catherine Zeta-Jones on Wednesday, briefly |
| 33% | LOWC | 4 | Note played by covering every hole on a recorder |
| 33% | SAX | 3 | Instrument played by Bleeding Gums Murphy on "The Simpsons" |
| 33% | TUG | 3 | ___ of war (game played by pulling on a rope) |
| 33% | THOR | 4 | Marvel superhero played by one of the Hemsworth brothers |
| 32% | PAM | 3 | Vampire played by Kristin Bauer van Straten on "True Blood" |