| 100% | NPR | 3 | Media network for Susan Stamberg, the first woman to anchor a nightly news program in the U.S. |
| 43% | AMYMCGRATH | 10 | First woman to fly an F/A-18 in combat for the U.S. Marine Corps |
| 39% | BLACKWELL | 9 | Elizabeth ___, British physician who was the first woman to earn a medical degree in the US |
| 38% | ANN | 3 | ___ Compton, first woman to cover the White House for a TV network |
| 36% | HARRIETQUIMBY | 13 | First woman to earn a pilot's license in the United States and the first woman to fly across the English Channel (2 wds.) |
| 36% | ROSAPARKS | 9 | First woman to lie in honor in the U.S. Capitol |
| 36% | LAPD | 4 | First law enforcement org. in the U.S. to hire a female officer (1910) |
| 36% | HONDAACCORD | 11 | First car from a Japanese manufacturer to be made in the U.S. (1982) |
| 36% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 36% | ALYSSANAKKEN | 12 | First woman to coach on the field of a Major League Baseball game, for the San Francisco Giants in 2020: 2 wds. |
| 35% | EILEEN | 6 | ___ Collins, American astronaut who became the first woman to command a space shuttle mission in 1999 |
| 35% | LEE | 3 | Rebecca ___ Crumpler (first Black woman to become a medical doctor in the US) |
| 35% | EDITH | 5 | Wharton who was the first woman to win a Pulitzer Prize for fiction |
| 35% | KATIESOWERS | 11 | First woman in the NFL to coach in a Super Bowl, for the San Francisco 49ers in 2020: 2 wds. |
| 35% | RONALDREAGAN | 12 | U.S. president who was the first born in Illinois, the first to have been divorced, and the first to nominate a woman to the Supreme Court (2 wds.) |
| 35% | LEE | 3 | Rebecca ___ Crumpler, physician who was the first African-American woman in the US to earn a medical degree |
| 35% | ITO | 3 | In 1981, she became the first woman to land a triple-triple jump combination in competition |
| 35% | ITO | 3 | Olympic skater who was the first woman to land a triple axel in competition |
| 35% | ITO | 3 | Skater Midori who was the first woman to land a triple axel in competition |
| 34% | ANNE | 4 | Sci-fi writer McCaffrey, who was the first woman to win a Hugo for fiction |
| 34% | DOMEE | 5 | Shi who was the first woman to have the sole director’s credit on a Pixar feature, for “Turning Red” |
| 34% | YENTL | 5 | Film for which Barbra Streisand became the first woman to win a Golden Globe for directing |
| 34% | JESMYNWARD | 10 | In 2017, she became the first woman to win two National Book Awards for fiction |
| 34% | OBERLIN | 7 | Ohio college that was the first in the U.S. to admit women |
| 33% | JOAN | 4 | ___ Rivers, comedian and actress who was the first woman to host a late-night network TV talk show |
| 33% | SUSANAMARTINEZ | 14 | In 2010, she became the first woman to be elected governor of New Mexico: 2 wds. |
| 33% | REBA | 4 | McEntire who is the first woman to portray Colonel Sanders in a KFC ad |
| 33% | CAROLEKING | 10 | "You've Got a Friend" singer/pianist who was the first woman to win a Grammy for Song of the Year (2 wds.) |
| 33% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 33% | LINCOLN | 7 | Abraham ___, 16th President of the U.S.A. and the first to sport a beard in office |