| 100% | CLAIREFINN | 10 | Medical officer played by Penny Johnson Jerald on 49-Across (2 wds.) |
| 51% | KELLYGRAYSON | 12 | Commander and first officer played by Adrianne Palicki on 49-Across (2 wds.) |
| 45% | JAMESOLSEN | 10 | Photographer played by Mehcad Brooks on 49-Across (2 wds.) |
| 44% | GORDONMALLOY | 12 | Helmsman and lieutenant played by Scott Grimes on 49-Across (2 wds.) |
| 44% | MAXGOODWIN | 10 | Medical director played by 37-Across on 29-Across (2 wds.) |
| 43% | JAMESGORDON | 11 | Police officer on "Gotham" played by 18-Across: 2 wds. |
| 42% | SONNYCROCKETT | 13 | Undercover detective played by Don Johnson on 52-Across (2 wds.) |
| 41% | JACKIEPEYTON | 12 | Nurse played by Edie Falco on a Showtime medical drama (2 wds.) |
| 41% | MAXGOODWIN | 10 | Hospital medical director played by 16-Across: 2 wds. |
| 40% | JOANCLAYTON | 11 | Character played by Tracee Ellis Ross on 17-Across: 2 wds. |
| 40% | KELLYBUNDY | 10 | Ditzy character played by 15-/50-Across on "Married... with Children": 2 wds. |
| 40% | PETERDINKLAGE | 13 | He plays Tyrion Lannister on 49-Across: 2 wds. |
| 39% | DONALDTRUMP | 11 | Presidential candidate who has been played by 17-Across on "Saturday Night Live": 2 wds. |
| 39% | DRWATSON | 8 | Holmes' assistant, played by 29-Across on 47-Across: 2 wds. |
| 39% | DEREKMORGAN | 11 | Special agent played by 39-Across on 29-Across: 2 wds. |
| 38% | UNCLEJESSE | 10 | Role played by 18-Across on "Full House": 2 wds. |
| 38% | ASHTONKUTCHER | 13 | "That '70s Show" actor who has been played by 17-Across on "Saturday Night Live": 2 wds. |
| 38% | LILITHSTERNIN | 13 | Psychiatrist played by Bebe Neuwirth on "Cheers": 2 wds. |
| 38% | LITTLEJOE | 9 | "Bonanza" brother played by 49-Across (2 wds.) |
| 37% | JOHNNYENGLISH | 13 | Inept British spy played by 49-Across in three films (2 wds.) |
| 37% | ALFREDBELLOWS | 13 | Psychiatrist played by Hayden Rorke on "I Dream of Jeannie": 2 wds. |
| 37% | ROSSGELLER | 10 | Geeky character played by David Schwimmer on "Friends": 2 wds. |
| 37% | MALREYNOLDS | 11 | Spaceship owner played by Nathan Fillion on "Firefly": 2 wds. |
| 37% | PHOEBEBUFFAY | 12 | Vegetarian masseuse played by Lisa Kudrow on "Friends": 2 wds. |
| 37% | RACHELBERRY | 11 | Vegetarian singer played by Lea Michele on "Glee": 2 wds. |
| 37% | THEDOCTOR | 9 | Time Lord whose 11th incarnation was played by 15-Across on a long-running BBC sci-fi series: 2 wds. |
| 37% | LORDVOLDEMORT | 13 | "Harry Potter" villain played by 49-Across (2 wds.) |
| 36% | BRENDAWALSH | 11 | Character played by 24-Across/37-Across on "Beverly Hills, 90210" (2 wds.) |
| 36% | KELLYKAPOWSKI | 13 | Bayside cheerleader played by Tiffani Thiessen on "Saved by the Bell": 2 wds. |
| 36% | LORELEILEE | 10 | "Gentlemen Prefer Blondes" character first played by 30-Across on Broadway (2 wds.) |