| 100% | DEBRA | 5 | Messing who played the latter title characters on “Ned and Stacey” and “Will & Grace” |
| 45% | GEORGECOSTANZA | 14 | Character who is Jerry's best friend since high school and is played by Jason Alexander on the show "Seinfeld": 2 wds. |
| 45% | WARREN | 6 | With 35-Across, actor who played Clyde, one of the title characters on the run in 1967's "Bonnie and Clyde" |
| 44% | EMMANUELLEWIS | 13 | Actor who played the title character on "Webster": 2 wds. |
| 44% | EDIE | 4 | Actress Falco who played the title character on "Nurse Jackie" |
| 44% | ALFIESOLOMONS | 13 | "Peaky Blinders" character, played by Tom Hardy, who ran a distillery and was seen on the show from season 2 till 4: 2 wds. |
| 44% | LILYCOLLINS | 11 | Actress who plays the title character on 46-Across (2 wds.) |
| 43% | WALKERSCOBELL | 13 | "The Adam Project" actor who plays the title hero on "Percy Jackson and the Olympians" (2 wds.) |
| 43% | EDIEFALCO | 9 | "The Sopranos" actress who played the title character on "Nurse Jackie": 2 wds. |
| 43% | LINDALAVIN | 10 | Actress who played the title character on the sitcom "Alice": 2 wds. |
| 43% | PEDROPASCAL | 11 | "Narcos" actor who plays the title character on "The Mandalorian" (2 wds.) |
| 43% | BROOKESHIELDS | 13 | "The Blue Lagoon" actress who played the title character on 46-Across (2 wds.) |
| 43% | DONJOHNSON | 10 | "Miami Vice" actor who played the title character on 40-Across (2 wds.) |
| 43% | LOUISAHARLAND | 13 | "Derry Girls" actress who plays the title character on 44-Across (2 wds.) |
| 43% | TOMHIDDLESTON | 13 | "Kong: Skull Island" star who plays the title character on "Loki": 2 wds. |
| 42% | CHRISTIANKANE | 13 | The actor who plays the lead character and genius Jacob Stone on "The Librarians": 2 wds. |
| 42% | CAMILLERAZAT | 12 | Actress who plays the title character's new friend on 46-Across (2 wds.) |
| 42% | BARBARABARRIE | 13 | "Breaking Away" actress who played the title character's Nana on 46-Across (2 wds.) |
| 42% | EMILYBLUNT | 10 | "The Girl on the Train" star who plays the title character in "Mary Poppins Returns": 2 wds. |
| 41% | ORSONWELLES | 11 | Actor who directed 17-Across and played the title character: 2 wds. |
| 41% | SARAHPAULSON | 12 | "American Horror Story" actress who plays the title character, 46-Across, on a Netflix miniseries (2 wds.) |
| 41% | CECILYSTRONG | 12 | "Ghostbusters" actress who played the recurring characters Cathy Ann and Kyra on "Saturday Night Live" (2 wds.) |
| 41% | CECILYSTRONG | 12 | "Ghostbusters" actress who plays the recurring characters Cathy Ann and Kyra on "Saturday Night Live" (2 wds.) |
| 41% | ANTHONYMACKIE | 13 | Actor who plays Falcon in the Marvel Cinematic Universe and has been on "Black Mirror": 2 wds. |
| 41% | LETITIAWRIGHT | 13 | Actress who plays Shuri in the Marvel Cinematic Universe and has been on "Black Mirror": 2 wds. |
| 41% | AIDA | 4 | Opera title character who has been played by Maria Callas and Leontyne Price |
| 41% | DIANE | 5 | ___ Chambers, character on the TV show "Cheers" who was played by Shelley Long |
| 41% | SAM | 3 | ___ Malone, character on the TV show "Cheers" who was played by Ted Danson |
| 41% | BLACKLIGHTNING | 14 | Superhero dad who was the title character on a show on a 2018-2021 CW show: 2 wds. |
| 41% | DANIELKALUUYA | 13 | Actor who plays W'Kabi in the Marvel Cinematic Universe and has been on "Black Mirror": 2 wds. |