| 100% | HATERADE | 8 | Metaphorical substance that's consumed critically? |
| 45% | ORE | 3 | Substance that's mined |
| 45% | LODESTONE | 9 | Substance that's attractive |
| 43% | GOO | 3 | Substance that's viscous and slimy |
| 43% | SAP | 3 | Substance that's turned into maple syrup |
| 42% | LYE | 3 | Substance that's a homophone of a falsehood |
| 41% | BOTOX | 5 | Substance that's used to help erase frown lines |
| 40% | POT | 3 | Substance that's legal in 11 states plus D.C. |
| 40% | TAR | 3 | Substance that's an anagram of 34- and 43-Across |
| 40% | COAL | 4 | Substance that’s central to the Pennsylvania Anthracite Heritage Museum |
| 40% | BIOHAZARD | 9 | Organic substance that's dangerous to human health |
| 39% | ANTIVENOM | 9 | Substance that can reverse a snake bite's effects |
| 38% | LIMESTONE | 9 | White substance that coated Giza's Great Pyramid |
| 38% | YEW | 3 | Florida tree that's critically endangered |
| 36% | JELLO | 5 | Dessert that's commonly consumed in shot form |
| 36% | ADULTERANT | 10 | Substance that decreases purity |
| 36% | EGGWHITES | 9 | Substance that surrounds yolks |
| 36% | LUBE | 4 | Substance that overcomes friction |
| 36% | ANTITOXIN | 9 | Substance that counteracts poison |
| 36% | EMETIC | 6 | Substance that causes vomiting |
| 36% | ORE | 3 | Substance that lacks refinement? |
| 36% | DISINFECTANT | 12 | Substance that destroys germs |
| 36% | SOLVENT | 7 | Substance that dissolves another |
| 36% | ORE | 3 | Metallic substance that's a resource in the game The Settlers of Catan |
| 36% | OXIDANTS | 8 | Substances that oxidize others |
| 35% | WAX | 3 | Substance that polishes linoleum floors |
| 35% | YEAST | 5 | Substance that makes bread rise |
| 35% | DYE | 3 | Substance that could color textiles |
| 35% | INDUCER | 7 | Substance that enhances enzyme production |
| 35% | ANTIGEN | 7 | Substance that stimulates antibody production |