| 100% | SPACELAB | 8 | Microgravity laboratory first flown into space on the Space Shuttle Columbia in 1983 |
| 38% | SALLY | 5 | ___ Ride, American astronaut who became the first American woman to fly in space in 1983 |
| 38% | KALPANACHAWLA | 13 | Indian American astronaut aboard the ill-fated Space Shuttle Columbia in 2003 who was on her second mission on the same shuttle: 2 wds. |
| 37% | ELLENOCHOA | 10 | First Hispanic woman in space, aboard the space shuttle Discovery in 1993: 2 wds. |
| 37% | MAEJEMISON | 10 | First African-American woman in space, aboard the space shuttle Endeavour in 1992: 2 wds. |
| 35% | EILEENCOLLINS | 13 | First female commander of a space shuttle, Columbia in 1999: 2 wds. |
| 34% | KATYPERRY | 9 | 15-Across, 9-Down, and 27-Down singer who flew into space on a Blue Origin flight in 2025 (2 wds.) |
| 34% | RIDE | 4 | She became the first American woman in space in 1983 |
| 33% | EILEEN | 6 | ___ Collins, American astronaut who became the first woman to command a space shuttle mission in 1999 |
| 31% | JEMISON | 7 | Mae __, US astronaut on the space shuttle |
| 31% | MARTHA | 6 | Little ___, rabbit who was the first of her kind to be launched into space in 1959 |
| 31% | VALENTINA | 9 | ___ Tereshkova, cosmonaut who became the first woman to fly in space in 1964 |
| 30% | KALPANA | 7 | ___ Chawla, American astronaut who became the first Indian woman to fly in space in 1997 |
| 30% | ENOS | 4 | Chimpanzee who flew into space in 1961 |
| 30% | OHIO | 4 | Home of the first man to walk on the moon, the first American to orbit Earth and the first American woman to walk in space |
| 30% | APRIL | 5 | Month in 2021 when NASA's Ingenuity became the first powered aircraft to fly on Mars |
| 29% | BACH | 4 | Baroque composer whose music was sent into space on the Voyager probes |
| 29% | SPUTNIK | 7 | First launch in the space race |
| 29% | SPUTNIK | 7 | The first artificial satellite sent into space |
| 28% | FRUITFLY | 8 | First living creature sent into Space, in 1947 |
| 28% | ROAM | 4 | Last word in the first line of "Home on the Range" |
| 28% | METGALA | 7 | Ball on the first Monday in May |
| 28% | GORDON | 6 | Cooper, whose call signal was "Faith 7" when he flew into space on May 15, 1963 |
| 28% | BELLS | 5 | "Jingle ___," iconic Christmas carol that was the first song played on musical instruments in space by Gemini 6 astronauts in 1965 |
| 28% | APOLLO | 6 | Space program that put the first people on the moon |
| 28% | COLUMBIA | 8 | Name of the first space shuttle, launched 1981 |
| 27% | NASA | 4 | Space agency that put the first man on the Moon: Abbr. |
| 27% | EILEEN | 6 | Collins who was the first woman Space Shuttle commander |
| 27% | MAE | 3 | The first black woman in space __ Jemison |
| 27% | SEDER | 5 | In Judaism, the ceremonial dinner held on the first night of Passover |