| 100% | RNA | 3 | Molecule with the bases G, U, A, and C |
| 59% | DNA | 3 | Molecule with A, C, T and G |
| 44% | DNA | 3 | Its code uses only the letters A, G, C and T |
| 42% | HUNTSMAN | 8 | "Snow White and the ___," fantasy film with a "cold" title based on a classic fairytale |
| 41% | RNA | 3 | Its components are often represented as G, U, A, and C, briefly |
| 41% | CHEESE | 6 | With 58-Across, savory base for a canapé ... and the function of a black square in four puzzle rows? |
| 39% | SHOHEI | 6 | With 34-Across, Dodgers pitcher who, in 2024, became the only player to hit 50 homers and steal 50 bases in a season |
| 38% | ALLIE | 5 | Brosh with the webcomic "Hyperbole and a Half" |
| 38% | ALPHABETTIES | 12 | Neckwear with the letters A, B, C, D, etc.? |
| 38% | TPAIN | 5 | Rapper with the 2007 #1 "Buy U A Drank" |
| 38% | GRANDSLAM | 9 | A home run with the bases loaded |
| 38% | ILLINOIS | 8 | The US state with Chicago and Springfield |
| 38% | BROKEN | 6 | With 49-Across, it keeps repeating itself ... and, based on the first and last letters, an apt description of each answer to a starred clue |
| 37% | NATO | 4 | Alliance with the US, Canada, and 29 European nations: Abbr. |
| 37% | AGUILERA | 8 | Christina with the hits "What a Girl Wants" and "Beautiful" |
| 37% | MLB | 3 | Sports org. with the A's, Jays, and Rays (Abbr.) |
| 37% | COMPOTE | 7 | Bowl with a base and stem |
| 37% | PUMPKIN | 7 | Make a Thanksgiving pie with us! (1/5) You'll need this star ingredient that gives the pie its name and deliciously smooth filling |
| 37% | WATER | 5 | With the answer below, dilute ... and a hint to the four longest answers |
| 37% | PSY | 3 | South Korean rapper with the US hits "Gangnam Style" and "Gentleman" |
| 37% | CUMULUS | 7 | A cloud with a flat base and heaped mounds |
| 37% | ORLANDO | 7 | US city with a Disney World and Universal Studios |
| 37% | ARCHERY | 7 | The art of shooting with a bow and arrow |
| 37% | HISTOLOGY | 9 | The study of cells and tissues with a microscope |
| 37% | MORMON | 6 | The Book of __, musical based on a US religion |
| 37% | OHIO | 4 | The only US state with a non-rectangular flag |
| 37% | DIME | 4 | US coin with a torch on the reverse side |
| 37% | TAG | 3 | Touch with the ball, as a base runner |
| 36% | TONIC | 5 | The "T" of a G and T |
| 36% | NORIEGA | 7 | Military strongman and longtime C.I.A. informant captured during the U.S. invasion of Panama |