| 100% | SETON | 5 | Mother ___ (first American saint) |
| 72% | SETON | 5 | ___ Hall University (New Jersey school named for the first American-born saint) |
| 62% | GLENN | 5 | First American orbiter |
| 61% | SETONS | 6 | American saint and family |
| 61% | GLENN | 5 | First American in orbit |
| 61% | SHEPARD | 7 | First American in space |
| 59% | GLENN | 5 | First American to orbit Earth |
| 59% | HALE | 4 | First American executed for spying |
| 59% | CLARKSON | 8 | First American Idol winner, Kelly __ |
| 59% | VONN | 4 | First American downhill Olympic champ |
| 59% | ADDAMS | 6 | First American woman Peace Nobelist |
| 59% | SALLYRIDE | 9 | First American woman in space |
| 59% | RIDE | 4 | First American woman in space |
| 58% | EDWHITE | 7 | First American to walk in space |
| 58% | JOHNGLENN | 9 | First American to orbit the Earth |
| 58% | EXPLORER | 8 | First American satellite, launched in 1958 |
| 58% | GLENN | 5 | First American to orbit the Earth |
| 58% | GGLLEENNNN | 10 | First American to orbit the earth |
| 58% | SETON | 5 | First U.S. saint |
| 58% | TERESA | 6 | Mother who was sainted |
| 57% | ELMO | 4 | Saint ___ Brady, first African American in the US to obtain a Ph.D. degree in chemistry (University of Illinois, 1916) |
| 57% | MOM | 3 | American mother |
| 57% | EVE | 3 | First mother |
| 57% | GRISSOM | 7 | First American to go into space twice |
| 57% | HARPERS | 7 | First American magazine to excerpt "Moby-Dick" |
| 57% | SYFY | 4 | First American Doctor Who licensee, at present |
| 57% | SALLYRIDE | 9 | First American woman in space: 2 wds. |
| 56% | ANDREWS | 7 | St. ___, first American links locale |
| 56% | DEANE | 5 | Silas ___, first American diplomat abroad |
| 56% | GLENN | 5 | John, first American in orbit |