| 100% | MELISSAARNOT | 12 | Mountaineer who climbed Mount Everest six times and became the first woman to survive a descent without supplemental oxygen: 2 wds. |
| 48% | EDMUNDHILLARY | 13 | Mountaineer who climbed Mount Everest with Tenzing Norgay and became the first climbers to have reached the summit of the mountain: 2 wds. |
| 43% | JORDANROMERO | 12 | Mountaineer who climbed Mount Everest at the age of 13 and later became the youngest climber in the world to complete the Seven Summits: 2 wds. |
| 34% | EDMUNDHILLARY | 13 | New Zealand mountaineer who was one of the first two people to conquer Mount Everest: 2 wds. |
| 33% | STEVIENICKS | 11 | American singer and songwriter who became the first woman to be inducted twice into the Rock and Roll Hall of Fame: 2 wds. |
| 32% | CANDICEBERGEN | 13 | Actress who was the first woman to host "Saturday Night Live," and the first woman to host five times (2 wds.) |
| 30% | WAYNEGRETZKY | 12 | Hockey legend who was the first since Bobby Orr to tally 100+ assists in a season, and did so 11 times: 2 wds. |
| 30% | JOANRIVERS | 10 | Comedian who was the first woman to host a late-night talk show on a major network: 2 wds. |
| 30% | JUNKO | 5 | ___ Tabei, Japanese mountaineer and the first woman to scale Mount Everest |
| 30% | TINAFEY | 7 | Actress/writer who was the first woman to be head writer of "Saturday Night Live," and the third woman to host five times (2 wds.) |
| 29% | MANNYPACQUIAO | 13 | Filipino boxer who recently became the first person to hold a world title in four different decades: 2 wds. |
| 28% | HARRIETQUIMBY | 13 | First woman to earn a pilot's license in the United States and the first woman to fly across the English Channel (2 wds.) |
| 28% | EVELYNASHFORD | 13 | The first track and field athlete to run 100 meters under 11 seconds in an Olympic Games and who has won a total of 5 Olympic medals: 2 wds. |
| 28% | SUSANAMARTINEZ | 14 | In 2010, she became the first woman to be elected governor of New Mexico: 2 wds. |
| 28% | NIKKIHALEY | 10 | In 2010, she became the first woman to be elected governor of South Carolina: 2 wds. |
| 28% | SARAHPALIN | 10 | In 2006, she became the first woman to be elected governor of Alaska: 2 wds. |
| 28% | DANICAPATRICK | 13 | Racing great who became the first woman driver to win an Indy car race in April 2008 (2 wds.) |
| 28% | TENZINGNORGAY | 13 | Sherpa who was one of the first two people to conquer Mount Everest: 2 wds. |
| 27% | RASHIDATLAIB | 12 | First woman of Palestinian descent to serve in Congress and the first Muslim woman to serve in the Michigan legislature (2 wds.) |
| 27% | LUKEAIKINS | 10 | American skydiver who was the first to land safely without a parachute or wingsuit from mid-tropospheric altitude: 2 wds. |
| 27% | EDITHWHARTON | 12 | 13-Across and 25-Across writer who was the first woman to win a Pulitzer Prize in Literature, for her 1920 novel "The Age of Innocence" (2 wds.) |
| 26% | ALYSSANAKKEN | 12 | First woman to coach on the field of a Major League Baseball game, for the San Francisco Giants in 2020: 2 wds. |
| 26% | EILEEN | 6 | ___ Collins, American astronaut who became the first woman to command a space shuttle mission in 1999 |
| 26% | SHERYL | 6 | I wrote "Lean In" and became the first woman to join Facebook's board of directors |
| 26% | LESLEYVISSER | 12 | First woman to report from the sidelines for a Super Bowl game (2 wds.) |
| 26% | TONIMORRISON | 12 | "Beloved" author who died August 5, and who was the first African-American woman to win a Nobel Prize: 2 wds. |
| 26% | RONALDREAGAN | 12 | U.S. president who was the first born in Illinois, the first to have been divorced, and the first to nominate a woman to the Supreme Court (2 wds.) |
| 26% | AMELIAEARHART | 13 | Aviation pioneer who was the first woman to fly solo across the Atlantic: 2 wds. |
| 26% | KATIESOWERS | 11 | First woman in the NFL to coach in a Super Bowl, for the San Francisco 49ers in 2020: 2 wds. |
| 26% | STANDBACK | 9 | 1983 top 10 hit for Stevie Nicks, the first woman to be inducted twice (in 1998 and 2019) into the Rock and Roll Hall of Fame: 2 wds. |