| 100% | YUK | 3 | Mr. ___ (poison symbol who turned 50 in 2021) |
| 66% | MARKWAHLBERG | 12 | "Boogie Nights" star who turns 50 in 2021 (2 wds.) |
| 66% | EWANMCGREGOR | 12 | "Star Wars" star who turns 50 in 2021 (2 wds.) |
| 59% | DAVIDTENNANT | 12 | "Doctor Who" star who turns 50 in 2021 (2 wds.) |
| 51% | MIKEPIAZZA | 10 | MLB Hall of Famer who turns 50 in 2018 (2 wds.) |
| 51% | BARRYSANDERS | 12 | NFL Hall of Famer who turns 50 in 2018 (2 wds.) |
| 51% | GARYPAYTON | 10 | NBA Hall of Famer who turns 50 in 2018 (2 wds.) |
| 42% | OLIVIACOLMAN | 12 | English actress known for 13-Across, 16-Across, and 34-Across who turns 50 years old in 2024 (2 wds.) |
| 39% | HBO | 3 | Movie network turning 50 in 2022 |
| 39% | SNL | 3 | NBC show turning 50 in 2025 |
| 39% | JAWS | 4 | Film that turned 50 in summer 2025 |
| 38% | JENNIFERLOPEZ | 13 | Multitalented superstar who turns 50 today (2 wds.) |
| 37% | FINNEY | 6 | "Erin Brockovich" star Albert who turned down the title role in 15-/50-Across |
| 37% | BRANDO | 6 | "The Godfather" star Marlon who turned down the title role in 15-/50-Across |
| 37% | SEANCOMBS | 9 | Rapper who turned 50 on November 4, 2019 (2 wds.) |
| 37% | TYLERPERRY | 10 | Entertainer who turns 50 on September 13, 2019 (2 wds.) |
| 36% | DANIELCRAIG | 11 | "Skyfall" actor who turned 50 on March 2, 2018 (2 wds.) |
| 36% | LLCOOLJ | 7 | Actor and rapper who turned 50 on January 14, 2018 (3 wds.) |
| 36% | MOLLYRINGWALD | 13 | "Sixteen Candles" actress who turned 50 on February 18, 2018 (2 wds.) |
| 35% | KENGRIFFEYJR | 12 | Baseball Hall of Famer who turned 50 on November 21, 2019 (3 wds.) |
| 35% | FAITHHILL | 9 | "This Kiss" country singer who turns 50 on September 21, 2017 (2 wds.) |
| 35% | HUGHJACKMAN | 11 | "The Greatest Showman" actor who turns 50 on October 12, 2018 (2 wds.) |
| 35% | PHARRELL | 8 | With 52-Across, "Happy" Grammy winner who turns 50 on April 5, 2023 |
| 35% | TEBOW | 5 | Football player Tim who turned baseball player in 2016 |
| 35% | LOTS | 4 | ___ wife (woman who turned to salt in the Bible) |
| 35% | SNOBS | 5 | People who turn their noses up in the air |
| 35% | ARROW | 5 | Symbol painted in a turn-only lane |
| 34% | STEFFIGRAF | 10 | Hall of Fame tennis great who turned 50 on June 14, 2019 (2 wds.) |
| 34% | JAMIEFOXX | 9 | "Ray" Best Actor Oscar winner who turns 50 on December 13, 2017 (2 wds.) |
| 34% | KIRKDOUGLAS | 11 | Actor who turned 100 in 2016: 2 wds. |