| 100% | BIGBIRD | 7 | Mr. Snuffleupagus's best friend on "Sesame Street" (2 wds.) |
| 57% | BERT | 4 | Ernie's best friend, on "Sesame Street" |
| 55% | ELMO | 4 | One of Zoe's best friends on "Sesame Street" |
| 53% | VALERIEHARPER | 13 | Actress who played Mary's best friend Rhoda on "The Mary Tyler Moore Show": 2 wds. |
| 53% | ELMO | 4 | Mr. Noodle's friend on "Sesame Street" |
| 50% | BERT | 4 | Ernie's best friend on "Sesame Street" for whom Ernie dedicated the song "That's What Friends Are For" |
| 50% | GEORGECOSTANZA | 14 | Character who is Jerry's best friend since high school and is played by Jason Alexander on the show "Seinfeld": 2 wds. |
| 49% | BARNEYRUBBLE | 12 | Bamm-Bamm's dad and Fred's best friend on 34-Across (2 wds.) |
| 49% | LIZZYCAPLAN | 11 | "Masters of Sex" actress who plays one of Toby Fleishman's best friends on "Fleishman Is in Trouble" (2 wds.) |
| 48% | AREA | 4 | "Diamonds ___ Girl's Best Friend": 2 wds. |
| 48% | COOKIEMONSTER | 13 | Blue Muppet on "Sesame Street": 2 wds. |
| 46% | FIREFLYLANE | 11 | Netflix series about two women who are longtime best friends, based on the Kristin Hannah novel: 2 wds. |
| 45% | MAX | 3 | Caroline's best friend on "2 Broke Girls" |
| 45% | ZOOEYDESCHANEL | 14 | "New Girl" star who helped renovate her best friend's house on "Celebrity IOU": 2 wds. |
| 43% | AREA | 4 | "Diamonds ___ Girl's Best Friend" (2 wds.) |
| 42% | MRSC | 4 | Richie's mom, to his friends on "Happy Days": 2 wds. |
| 42% | LARAFLYNNBOYLE | 14 | "The Practice" actress who played murder victim Laura Palmer's best friend Donna on "Twin Peaks": 3 wds. |
| 42% | ANDREABARBER | 12 | Actress who played Kimmy Gibbler, D.J's best friend in the 1987 sitcom "Full House:" 2 wds. |
| 42% | ELMO | 4 | Zoe's red friend on "Sesame Street" |
| 42% | ERNIE | 5 | Bert's friend on "Sesame Street" |
| 42% | BERT | 4 | Ernie's friend on "Sesame Street" |
| 42% | ELMO | 4 | Zoe's friend on "Sesame Street" |
| 42% | JERRYROBINSON | 13 | Bob's orthodontist friend on "The Bob Newhart Show," played by Peter Bonerz: 2 wds. |
| 41% | ELMO | 4 | Red Muppet on "Sesame Street" whose best friend is a pink fairy named Abby Cadabby |
| 41% | JOEY | 4 | Chandler's best friend on "Friends" |
| 41% | ELAINE | 6 | Jerry's best friend on "Seinfeld" |
| 41% | ABED | 4 | Troy's best friend on "Community" |
| 41% | ISSA | 4 | Molly’s best friend on “Insecure” |
| 41% | JOENAMATH | 9 | Jets quarterback who counted backwards on "Sesame Street" in 1975: 2 wds. |
| 41% | MRNOODLE | 8 | Clown played by Bill Irwin on "Sesame Street" (2 wds.) |