| 100% | POISONED | 8 | Murdered by toxins |
| 56% | TYBALT | 6 | Capulet murdered by Romeo |
| 55% | DUNCAN | 6 | Scottish king, murdered by Macbeth |
| 55% | DUNCAN | 6 | Scottish king murdered by Macbeth |
| 53% | AGAMEMNON | 9 | Greek king murdered by wife Clytemnestra |
| 53% | ABEL | 4 | Biblical character murdered by brother Cain |
| 53% | TYBALT | 6 | Cousin of Juliet murdered by Romeo |
| 53% | ALEC | 4 | d'Urberville rake murdered by Tess |
| 53% | VENOM | 5 | Toxin secreted by animals |
| 52% | ABEL | 4 | Biblical character murdered by his brother Cain |
| 52% | MARVIN | 6 | __ Gaye, smooth singer murdered by his father |
| 51% | ABEL | 4 | Biblical shepherd who was murdered by his brother |
| 49% | ORIENT | 6 | Murder on the __ Express by Agatha Christie |
| 46% | LAURA | 5 | 1944 murder mystery directed by Otto Preminger |
| 44% | MOUSETRAP | 9 | The __, UK murder mystery play by Agatha Christie |
| 42% | SELLERS | 7 | "Murder by Death" actor |
| 42% | HEPATITIS | 9 | Inflammation of the liver caused by a virus or toxin |
| 41% | MORO | 4 | Aldo —, prime minister of Italy from 1974-76 murdered by the Red Brigades in 1978 |
| 41% | SPOOF | 5 | "Murder by Death," e.g. |
| 41% | FORCEOFNATURE | 13 | Murder mystery by 43-Across set in the remote Australian bushland (3 wds.) |
| 41% | THELOSTMAN | 10 | Murder mystery by 43-Across set in the remote Australian outback (3 wds.) |
| 40% | DIAL | 4 | "___ M for Murder," 1954 crime mystery film directed by Alfred Hitchcock |
| 40% | RUE | 3 | "The Murders in the ___ Morgue" (short story by Edgar Allan Poe) |
| 40% | RUE | 3 | "The Murders in the ___ Morgue," short story by Edgar Allan Poe |
| 40% | CLAREQUILTY | 11 | Author of playlet The Enchanted Hunters murdered by Humbert Humbert in 1955 Vladimir Nabokov novel Lolita |
| 40% | MYLAI | 5 | — Massacre, mass murder by US army soldiers of over 300 civilians in South Vietnam in 1968 |
| 38% | MARTIN | 6 | Name shared by two of the stars of "Only Murders in the Building" |
| 38% | GLASSONION | 10 | 2022 murder mystery movie with cameos by Serena Williams and Yo-Yo Ma |
| 38% | POKERFACE | 9 | Natasha Lyonne murder mystery series on Peacock created by 39-Across: 2 wds. |
| 37% | SPOOFS | 6 | "Murder by Death" and "Young Frankenstein," e.g. |