| 100% | JOHNNYBRAVO | 11 | Muscular title character in a 1997-2004 Cartoon Network series: 2 wds. |
| 71% | SAMURAIJACK | 11 | Sword-wielding title character in a 2001-2004 and 2017 Cartoon Network series: 2 wds. |
| 65% | STEVENUNIVERSE | 14 | Half-human, half-alien title character in a current Cartoon Network series: 2 wds. |
| 55% | AQUATEEN | 8 | Any of three title characters in a long-running Cartoon Network series |
| 54% | RICHARDCASTLE | 13 | Writer who was the title character in a 2009-2016 crime series: 2 wds. |
| 48% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 46% | ADVENTURETIME | 13 | Animated Cartoon Network series set in the Land of Ooo: 2 wds. |
| 45% | DEPUTYDAWG | 10 | Title character in a 1960s US television cartoon series whose supporting cast included Muskie Muskrat and Vincent van Gopher |
| 45% | ULEE | 4 | Title character in a 1997 bee movie |
| 44% | MISSDAISY | 9 | Title character whom 15-Across chauffeured around in a 1989 film: 2 wds. |
| 44% | MAGGIESIMPSON | 13 | Cartoon character with a blue hair bow whose long-running series debuted in 1989 (2 wds.) |
| 43% | BUTCHCASSIDY | 12 | Title character in a classic western film who asks, "Who are those guys?" (2 wds.) |
| 43% | DEPUTYDAWG | 10 | Title character in a US television cartoon series that debuted in 1960 whose supporting cast included Ty Coon and Vincent Van Gopher |
| 43% | RAMONA | 6 | Title character in a Beverly Cleary book series |
| 42% | DHARMA | 6 | Title character in a new 1997 ABC sitcom |
| 42% | RAMONA | 6 | Title character in a series of Beverly Cleary books |
| 42% | SHREK | 5 | Title character in a series of four DreamWorks animated films |
| 41% | JAMESMCAVOY | 11 | "X-Men: Apocalypse" star who played the title character of 28-Across in a 2015 movie: 2 wds. |
| 40% | LEADROLES | 9 | Main characters in a movie: 2 wds. |
| 40% | CRAIGOFTHECREEK | 15 | Cartoon Network series set in a parent-free forest wonderland |
| 38% | TOMHARDY | 8 | "Inception" actor who plays the title character in "Venom": 2 wds. |
| 38% | MARGOTROBBIE | 12 | "Babylon" actress who plays the title character in "Barbie": 2 wds. |
| 38% | BILLIEJEAN | 10 | Title woman in a 1983 hit single by Michael Jackson: 2 wds. |
| 38% | PEGGYSUE | 8 | Title woman in a 1957 hit single by Buddy Holly: 2 wds. |
| 38% | DAWSONSCREEK | 12 | Classic high-school drama series on the WB whose title character lives near a stream in Capeside, Massachusetts: 2 wds. |
| 37% | ONTOUR | 6 | Performing concerts in a series of locations: 2 wds. |
| 37% | KARENFUKUHARA | 13 | "Suicide Squad" actress who voices the title character in 14-/32-Across: 2 wds. |
| 37% | EZRAMILLER | 10 | Actor who plays the title character in the new movie "The Flash": 2 wds. |
| 37% | KENNETHBRANAGH | 14 | Actor who directed and played the title character in 1996's "Hamlet": 2 wds. |
| 37% | GIJOE | 5 | Military action figure featured in a 1980s cartoon: 2 wds. |