| 100% | NEMEANLION | 10 | Mythological creature slayed and skinned by Heracles as the first of his twelve labours |
| 34% | ATOMICPILE | 10 | The first one of these was built by Fermi and his team in 1942 |
| 31% | CHIMERA | 7 | Mythological creature described by Homer as "in the fore part a lion, in the hinder a serpent, and in the midst a goat" |
| 31% | PELOPS | 6 | Son of Tantalus in Greek mythology killed by his father and served to the gods as a meal |
| 30% | BALROG | 6 | Creature slain in the Mines of Moria by Gandalf |
| 30% | DONOVAN | 7 | 2012 Rock and Roll Hall of Fame inductee who went by his first name only and had the hit "Mellow Yellow" |
| 29% | KWAME | 5 | ___ Nkrumah, Ghanaian politician who served as the first Prime Minister and President of Ghana |
| 27% | HAN | 3 | First name of the character played by Harrison Ford and Alden Ehrenreich |
| 27% | VCR | 3 | The first commercial one of these was introduced by Ampex in 1956 and cost roughly $50,000 |
| 27% | EMMA | 4 | Title heroine described in the first sentence of her novel as "handsome, clever and rich" |
| 27% | EMMA | 4 | Title heroine described in the first lines of her novel as "handsome, clever and rich" |
| 27% | OBAMA | 5 | President with the same first and last name as his father |
| 27% | MARINERS | 8 | Seattle team where 41-Across played the first 11 and last two seasons of his career |
| 27% | KINGJOHN | 8 | The Life and Death of —, stage play by William Shakespeare first published in 1623 |
| 27% | KAYAK | 5 | Style of boat first used by the Aleut, Inuit, and Yupik peoples |
| 27% | UMIAK | 5 | Open boat made of skin used by the Yupik and Inuit peoples |
| 26% | CANYOU | 6 | & 10D First of the Palliser novels by Anthony Trollope published in serial form in 1864 and 1865 |
| 26% | PINTA | 5 | The —, one of three ships commanded by Christopher Columbus on his first voyage to America |
| 26% | BERTIE | 6 | King Edward VII of the UK known by his family as this nickname |
| 26% | KEEPSANEYEON | 12 | Looks after, as suggested by the last word of 20-, 29- and 46-Across |
| 26% | ONION | 5 | Common veggie capable of producing excellent brown and yellow dyes simply by boiling the skin |
| 26% | ELVISPRESLEY | 12 | Singer known as the "The King of Rock and Roll" whose first hit singles were with Sun Records (2 wds.) |
| 25% | PERICLES | 8 | Known as the first citizen of Athens |
| 25% | TWENTYQUESTIONS | 15 | Game suggested by the first words of 17-, 25- and 42-Across |
| 25% | MATINEEIDOL | 11 | Figure described by the first words of 17-, 28- and 45-Across |
| 25% | ELLA | 4 | Fitzgerald known as the First Lady of Song |
| 25% | IDINA | 5 | Real first name of the singer introduced by John Travolta at the 2014 Oscars as "Adele Dazeem" |
| 25% | ELLAFITZGERALD | 14 | Music legend known as the First Lady of Song |
| 25% | MOTHRA | 6 | Giant moth-like creature featured in the "Godzilla" films as a good monster and protector of the Earth |