| 100% | GEMINI | 6 | NASA's second human spaceflight program |
| 52% | VOSTOK | 6 | Soviet human spaceflight program |
| 41% | ORION | 5 | Spacecraft of NASA's Artemis program |
| 41% | NEEMO | 5 | NASA's underwater program |
| 41% | APOLLO | 6 | NASA's lunar program |
| 38% | ARTEMIS | 7 | NASA's return-to-the-moon program |
| 38% | CHALLENGER | 10 | NASA's second Space Shuttle orbiter constructed by Rockwell International |
| 37% | MARS | 4 | One target of NASA's Mariner program |
| 35% | ARTEMIS | 7 | ___ Program, NASA's crewed flight program since 2017 |
| 35% | APOLLOI | 7 | First crewed mission in NASA's Moon landing program |
| 35% | MARS | 4 | Focus of NASA’s Viking program |
| 34% | APOLLO | 6 | US spaceflight program |
| 34% | NASA | 4 | Org. with an Artemis spaceflight program |
| 34% | RERUN | 5 | Second showing of a TV program |
| 34% | EVE | 3 | Second human mentioned in the Bible |
| 34% | VOSTOK | 6 | Soviet human spaceflight mission |
| 33% | APOLLO | 6 | NASA program |
| 33% | EVE | 3 | The second human, in Christianity |
| 33% | CHALLENGER | 10 | NASA's space shuttle that broke apart 73 seconds after take off in 1986 |
| 33% | APOLLO | 6 | Nasa lunar program |
| 32% | MAE | 3 | Astronaut Jemison, the first African-American woman in NASA's training program |
| 32% | EVE | 3 | The second human, in the Bible |
| 32% | MICROCHIPS | 10 | NASA's Apollo Program was the largest single consumer of these in the early 1960s |
| 32% | APOLLO | 6 | NASA moon landing program |
| 32% | TIBIA | 5 | Second-longest human bone |
| 31% | MIR | 3 | Site of the longest single human spaceflight |
| 31% | RERUN | 5 | Second airing of a program |
| 31% | GEMINI | 6 | Early NASA program |
| 31% | ELEVENMINUTES | 13 | Approximate duration of 18-Across's first human spaceflight (2 wds.) |
| 30% | ARTEMIS | 7 | NASA moon exploration program since 2017 |