| 100% | ISE | 3 | Nasdaq ___, launched in 2000 and the first all-electronic trader in US equity options (abbr.) |
| 35% | CBS | 3 | "The Eye" network that was launched in 1947 and was a popular binge-worthy option before Netflix: Abbr. |
| 34% | DOB | 3 | First lesbian civil and political rights org. in the US, formed in 1955 (abbr.) |
| 32% | LINCOLN | 7 | Abraham ___, 16th President of the U.S.A. and the first to sport a beard in office |
| 32% | EVA | 3 | Spacewalk performed by the first all-female team in 2019 (Abbr.) |
| 32% | SEP | 3 | Labor Day month, in the US and Canada: Abbr. |
| 32% | NSA | 3 | Security and surveillance body in the U.S.: Abbr. |
| 32% | BUD | 3 | Dog included in the first automobile trip across the US, with Horatio Nelson Jackson and Sewall K. Crocker |
| 31% | PIONEER | 7 | — 10, US spacecraft launched in 1972 that made the first fly-by of Jupiter |
| 31% | USA | 3 | ___ Network, "Burn Notice" network that was launched in 1977 and was a popular binge-worthy option before Netflix: Abbr. |
| 31% | ICA | 3 | Arts museums in Boston, Philadelphia, and Richmond, all of the same name : Abbr. |
| 31% | CALLSIGNS | 9 | They all start with "K" and "W" in the U.S. |
| 31% | YDS | 3 | The ten in "first and ten": Abbr. |
| 30% | NSA | 3 | Body in charge of security and surveillance in the U.S.: Abbr. |
| 30% | UAW | 3 | American labor union representing workers in the U.S. and Canada: Abbr. |
| 30% | MCCAFE | 6 | Fast food concept and brand launched in Melbourne, Australia in 1993 that finally hit the US in Chicago in 2001 |
| 30% | DEL | 3 | The first state to ratify the US Constitution: Abbr. |
| 30% | CNN | 3 | The first all-news channel in the United States |
| 30% | FANTASIA | 8 | __ 2000, the first animated film released in IMAX |
| 30% | PROVOLONE | 9 | In favor of the first book?: Abbr. |
| 30% | BELLE | 5 | First song in "Beauty and the Beast" |
| 30% | PALMSPRINGS | 11 | California city that, in 2018, became the first U.S. city to have an all-L.G.B.T. city council |
| 29% | GETHAPPY | 8 | Song sung by Judy Garland in "Summer Stock," and what the first halves of the starred answers can all do |
| 29% | YMCA | 4 | The first US one opened in Boston in 1851 |
| 29% | AMER | 4 | The "A" in U.S.A.: Abbr. |
| 29% | DEL | 3 | The first US state: Abbr. |
| 29% | ORIG | 4 | In the first place: abbr. |
| 29% | OMOO | 4 | Novel that ends "By noon, the island had gone down in the horizon; and all before us was the wide Pacific" |
| 29% | BLACKWELL | 9 | Elizabeth, the first female doctor in the US |
| 29% | CREE | 4 | Native Americans in Canada and the northern US |