| 100% | CARMENSANDIEGO | 14 | Netflix animated adventure series featuring the voice of 49-Across as the title character (2 wds.) |
| 54% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 43-Across (2 wds.) |
| 54% | FAMILYGUY | 9 | Animated TV series featuring the voices of Seth MacFarlane and 42-Across (2 wds.) |
| 50% | ASTROBOY | 8 | Manga-based animated film featuring the voice of 28-Across as a robot named Mr. Squeegee (2 wds.) |
| 50% | FAMILYGUY | 9 | Seth MacFarlane animated series featuring the voices of 15-Across, 26-Across, and 34-Across that debuted in 1999 (2 wds.) |
| 47% | STEVENUNIVERSE | 14 | Cartoon Network animated series that featured Susan Egan as the voice of the Crystal Gems' former leader Rose Quartz (2 wds.) |
| 47% | WILLARNETT | 10 | Voice of the title character on 36-Across: 2 wds. |
| 47% | HARLEYQUINN | 11 | HBO Max animated series, about the Joker's ex-girlfriend, that features the voice of Alan Tudyk: 2 wds. |
| 46% | MONSTERSINC | 11 | Animated film featuring 42-Across as the voice of a green, one-eyed scarer assistant named Mike Wazowski (2 wds.) |
| 45% | BOBSBURGERS | 11 | Fox animated sitcom that once featured the voice of "Mad Men" star Jon Hamm as a toilet (2 wds.) |
| 45% | WRECKITRALPH | 12 | 2012 animated film featuring the voices of John C. Reilly and Sarah Silverman: 2 wds. |
| 44% | KUNGFU | 6 | "___ Panda," 2008 animated movie featuring the voice of Jack Black: 2 wds. |
| 44% | MALCOLMX | 8 | Biopic directed by 49-Across featuring 49-Across as Shorty, a childhood friend of the title civil rights activist (2 wds.) |
| 44% | ICEAGE | 6 | Animated film franchise featuring the voice of Ray Romano (2 wds.) |
| 44% | ROGUEONE | 8 | "Star Wars" prequel film featuring the voice of 28-Across as a droid named K-2SO (2 wds.) |
| 44% | MORRISCHESTNUT | 14 | Actor who plays the title character of 47-Across in a CBS series that premiered in January: 2 wds. |
| 42% | POLAR | 5 | "The ___ Express," 2004 Christmas adventure film featuring the voice of Tom Hanks as the narrator |
| 42% | MODOK | 5 | 2021 animated series based on a Marvel Comics character and featuring the voices of Aimee Garcia and Ben Schwartz |
| 42% | KEVINCOSTNER | 12 | "Field of Dreams" actor who starred as the title character in the 1990 film "Dances With Wolves": 2 wds. |
| 42% | ARCHER | 6 | FX animated comedy series featuring H. Jon Benjamin as the voice of a narcissistic spy |
| 42% | TRES | 4 | "Maya y los ___" (animated Netflix series featuring the voices of Zoe Saldaña and Rita Moreno) |
| 42% | ROBERTYOUNG | 11 | He starred as the title character on 28-Across: 2 wds. |
| 42% | DOCTORWHO | 9 | BBC sci-fi series in which 31-Across plays the 10th and 14th incarnations of the title character: 2 wds. |
| 42% | THECROODS | 9 | 2013 animated film set in the Pliocene Era featuring the voice of 43-Across (2 wds.) |
| 41% | KALEYCUOCO | 10 | "The Flight Attendant" actress who voices the title character on HBO Max's animated "Harley Quinn": 2 wds. |
| 41% | MICHAELCERA | 11 | "Arrested Development" actor who voices the title character in Netflix's "Scott Pilgrim Takes Off": 2 wds. |
| 41% | NEVERHAVEIEVER | 14 | 2020-2023 Netflix series featuring Niecy Nash-Betts as the therapist of teenager Devi Vishwakumar: 4 wds. |
| 41% | MOANA | 5 | 2016 animated film featuring the voice of Dwayne Johnson as the demigod Maui |
| 41% | MELBLANC | 8 | The voice of 15-Across and many other Looney Tunes characters: 2 wds. |
| 41% | DONKEYKONG | 10 | Classic arcade game released by Nintendo in 1981 that features the adventures of a gorilla character: 2 wds. |