| 100% | MURDERERSROW | 12 | Nickname for the first six hitters of the 1927 Yankees lineup (which included 45-Across) (2 wds.) |
| 36% | ASONG | 5 | "Sunrise: ___ of Two Humans," 1927 silent romantic drama that won the first Academy Award for Best Cinematography in 1929: 2 wds. |
| 35% | BIGTHREE | 8 | Nickname for the dominant tennis trio of Roger Federer, Rafael Nadal, and Novak Djokovic: 2 wds. |
| 35% | HIGHERLOVE | 10 | 1986 #1 hit for 30-Across, which won the Grammy for Record of the Year: 2 wds. |
| 35% | FROZENFOUR | 10 | Nickname for the last two rounds of the NCAA hockey championship (2 wds.) |
| 35% | IRONHORSE | 9 | The ___, nickname given to baseballer Lou Gehrig of the New York Yankees: 2 wds. |
| 35% | MELC | 4 | Another nickname for Sporty Spice, one of the Spice Girls: 2 wds. |
| 34% | JACKNICKLAUS | 12 | He was nicknamed "The Golden Bear" of golf and holds a record for the highest number of wins in Masters Tournament with six titles: 2 wds. |
| 34% | WINTERSBONE | 11 | 2010 film set in the Ozarks for which 15-/48-Across received her first Oscar nomination: 2 wds. |
| 34% | MANU | 4 | English football club which won the inaugural Laureus team of the year in 2000, for short: 2 wds. |
| 34% | BROTHERLYLOVE | 13 | "The City of ___," nickname for Philadelphia which was also called "The City that Loves You Back" in an ad campaign: 2 wds. |
| 34% | KILLINGFLOOR | 12 | Debut novel by 25-Across that was the basis for the first season of "Reacher" (2 wds.) |
| 33% | MATTSMITH | 9 | "Doctor Who" actor who plays Prince Philip for the first two seasons of "The Crown" (2 wds.) |
| 33% | JLO | 3 | Nickname of the singer known for "All I Have" and "On the Floor": 2 wds. |
| 33% | BILLCULLEN | 10 | First host of "The Price Is Right," which debuted in 1956: 2 wds. |
| 33% | DOWNEAST | 8 | One nickname for the state of Maine (2 wds.) |
| 33% | BIGMACHINE | 10 | ___ Records, American record label for the likes of Tim McGraw, through which 16a will be released: 2 wds. |
| 32% | INSIDEMAN | 9 | 2006 film in which Denzel Washington plays a detective negotiating for the release of hostages: 2 wds. |
| 32% | KITHARINGTON | 12 | "Game of Thrones" actor whose first name is also the term for a baby fox: 2 wds. |
| 32% | ACETYL | 6 | First six letters of the proper name for aspirin |
| 32% | CLAIREFOY | 9 | "Wolf Hall" actress who plays Queen Elizabeth II for the first two seasons of "The Crown" (2 wds.) |
| 32% | KELLYCLARKSON | 13 | 16-Across and 45-Across singer who won the first season of "American Idol" (2 wds.) |
| 32% | LARAINENEWMAN | 13 | Female member of the first "Saturday Night Live" cast, known for playing Connie Conehead: 2 wds. |
| 32% | COMICBOOK | 9 | Setting for each of the places in 15-, 21-, and 41-Across: 2 wds. |
| 32% | MELC | 4 | Nickname for "Sporty Spice" of the Spice Girls (2 wds.) |
| 31% | IANMCEWAN | 9 | British author of the novel upon which 17-Across is based: 2 wds. |
| 31% | CRYSTALBALL | 11 | Nickname of the championship trophy awarded to 18-Across: 2 wds. |
| 31% | IWANTED | 7 | "Everything ___," song by Billie Eilish which won the Grammy for Record of the Year in 2021: 2 wds. |
| 31% | OLDGLORY | 8 | Nickname for the American flag: 2 wds. |
| 31% | MISTYCOPELAND | 13 | First black female principal dancer of the 35-/47-Across: 2 wds. |