| 100% | LIV | 3 | Nickname of the main character on "Scandal" |
| 72% | TONY | 4 | First name of the main character on "The Sopranos" |
| 71% | LUC | 3 | Jean-___ (first name of the main character on "Picard") |
| 71% | CARTMAN | 7 | Eric ___, one of the main characters on "South Park" |
| 70% | CALTECH | 7 | Nickname of the school where the main characters on "The Big Bang Theory" worked |
| 68% | HANK | 4 | Main character on "King of the Hill" |
| 60% | LIV | 3 | The main character on "iZombie" |
| 60% | CRAZYEYES | 9 | Nickname of Uzo Aduba's character on "Orange Is the New Black": 2 wds. |
| 60% | HOMER | 5 | The main character on "The Simpsons" |
| 58% | ISABELSANFORD | 13 | Actress who played Louise Jefferson, the main character on the '70s sitcom "The Jeffersons" which is one of the longest-running sitcoms: 2 wds. |
| 57% | TEENS | 5 | The main characters on Netflix's "Heartbreak High," e.g. |
| 56% | ALEXANDER | 9 | First name of the main character of 28-Across |
| 56% | DON | 3 | Draper who's the main character on "Mad Men" |
| 56% | SKYWALKER | 9 | Last name of the main character in Star Wars |
| 56% | DRS | 3 | All the main characters on "Grey's Anatomy" (Abbr.) |
| 56% | MDS | 3 | Most of the main characters in "Private Practice": Abbr. |
| 56% | ZACK | 4 | Main character on “Saved by the Bell” |
| 56% | BABYYODA | 8 | Nickname of the child on The Mandalorian |
| 56% | ABE | 3 | Nickname of the president on the penny |
| 56% | DRE | 3 | Nickname of the dad on "Black-ish" |
| 55% | LARACROFT | 9 | The main character of the Tomb Raider games |
| 55% | ABE | 3 | Nickname of the president on the $5 bill |
| 55% | RANGEBEDFELLOWS | 15 | The main characters of "Brokeback Mountain," e.g.? |
| 55% | KLU | 3 | "Big ___", nickname of the Reds slugger of the fifties who has a statute on the main entrance plaza of the Great American Ball Park |
| 55% | RAPUNZEL | 8 | __ is the main character of Tangled |
| 55% | DOM | 3 | First name of the main character in the "Fast & Furious" movies |
| 55% | RON | 3 | Weasley, one of the main characters in the "Harry Potter" series |
| 54% | DRE | 3 | Nickname of the dad on ABC's "Black-ish" |
| 54% | FIGHTCLUB | 9 | Tyler Durden is the main character of __ |
| 54% | GEEKY | 5 | Like the main characters of "Stranger Things" |