| 100% | RATE | 4 | Normal heart ___ is between 60 to 100 bpm |
| 34% | HEARTRATE | 9 | It's typically 60 to 100 beats per minute: 2 wds. |
| 30% | YDS | 3 | There are 100 between NFL end zones (Abbr.) |
| 30% | WILCO | 5 | "I Am Trying to Break Your Heart" band |
| 30% | AORTAS | 6 | Vessels that are close to people's hearts |
| 30% | BRUTUS | 6 | To Shakespeare he was "high in all the people's hearts" |
| 30% | SARI | 4 | There are more than 100 ways to drape it |
| 29% | CPR | 3 | Emergency procedure that should be performed at 100-120 bpm |
| 29% | CIRCULATE | 9 | The heart's job is to __ blood throughout the body |
| 29% | LIVES | 5 | A cat is said to have 60-Across of them |
| 28% | ELECTRIC | 8 | Defibrillation is an __ shock to the chest or heart |
| 28% | ICARIA | 6 | Greek island which is known to have higher than normal life expectancy |
| 28% | MANTHATSHARD | 12 | Paradoxical answer to "What isle is located between Ireland and Great Britain?" |
| 28% | STRAITARTIST | 12 | Applicant must be able to paint the area between Alaska and Russia |
| 28% | SHOWSTOPPER | 11 | Big musical number ... or what 60-Across is to four puzzle answers? |
| 28% | QUEEN | 5 | ___ of Hearts, "Alice in Wonderland" character whose name is connected to 13a |
| 28% | RHINOS | 6 | Large Sumatran beasts that now are estimated to number less than 100 |
| 27% | HUNT | 4 | 100/100 Marsha ___, actress from the film "Born to the West" who was a centenarian |
| 27% | USER | 4 | What a PEBCAK (“Problem Exists Between Chair And Keyboard”) error is attributed to |
| 27% | TEEN | 4 | Children between the ages of 10 to 12 are known as pre___s |
| 27% | ORR | 3 | He was the first hockey player to have 100 assists in one season |
| 27% | GLORIASTUART | 12 | "The Invisible Man" and "Titanic" actress who lived to be 100: 2 wds. |
| 27% | GOOGOL | 6 | 1 followed by 100 zeroes, not to be confused with the search engine |
| 27% | PORTAL | 6 | ___ Gun, gadget from "Rick and Morty" that is used to travel between different universes |
| 27% | NEO | 3 | Character who is asked to choose between a red pill and a blue pill |
| 27% | GEORGEBURNS | 11 | "Oh, God!" and "The Sunshine Boys" actor who lived to be 100: 2 wds. |
| 27% | SLEPT | 5 | Was between sheets |
| 26% | MANX | 4 | Breed once thought by some to be a cross between a cat and a rabbit |
| 26% | MARIOLEMIEUX | 12 | Penguins center who was the third player to have a 100-assist season: 2 wds. |
| 26% | IDLE | 4 | Be between jobs, say |