| 100% | ONEDAYATATIME | 13 | Norman Lear sitcom about a single mom and her daughters, revived in 2017: 5 wds. |
| 39% | THEJEFFERSONS | 13 | Norman Lear sitcom about a dry-cleaning entrepreneur: 2 wds. |
| 39% | SANFORDANDSON | 13 | Norman Lear sitcom about a curmudgeonly junk dealer: 3 wds. |
| 38% | ONEDAYATATIME | 13 | Netflix reboot of a 1970s sitcom about a single mom's family: 5 wds. |
| 37% | GIRLS | 5 | "Gilmore ___," TV series starring Lauren Graham that follows a single mom and her daughter's journey |
| 34% | ALLINTHEFAMILY | 14 | Norman Lear sitcom starring 16-Across and 35-Across that debuted in January 1971 (4 wds.) |
| 33% | ONEDAYATATIME | 13 | CBS sitcom about a divorced mother raising two teenaged daughters that ran from 1975 to 1984: 5 wds. |
| 32% | ALICE | 5 | Old sitcom about a single mom working at a Phoenix diner |
| 32% | GILMOREGIRLS | 12 | Quirky 2000-2007 drama about a mother and daughter living in Stars Hollow, Connecticut: 2 wds. |
| 31% | REBA | 4 | 2001-2007 sitcom about a single mother in Houston |
| 30% | REBA | 4 | Single mom in a 2000s sitcom |
| 30% | MALIBUCOUNTRY | 13 | Sitcom about a divorced mom who relocates to California: 2 wds. |
| 30% | TIME | 4 | "One Day at a ___," 2017 sitcom starring Justina Machado that is about a single mother and her two kids |
| 29% | THEGOLDBERGS | 12 | ABC sitcom about a geeky boy growing up in the 1980s: 2 wds. |
| 28% | BROADCITY | 9 | Sitcom about Abbi and Ilana in the Big Apple: 2 wds. |
| 28% | THEODDCOUPLE | 12 | 1970-1975 sitcom about a slob and a neatnik who lived together: 3 wds. |
| 27% | EFFIE | 5 | Avis Hotchkiss' daughter who drove with her mom in completing the 9000 mile trip from NY to SF and back in 1915 on a Harley-Davidson |
| 27% | SINGLEPARENTS | 13 | ABC sitcom about divorced moms and dads starring 18-Across and 41-Across (2 wds.) |
| 27% | LEAVINGTIME | 11 | 2014 novel by 45-Across about a daughter investigating her mother's disappearance (2 wds.) |
| 27% | FREAKYFRIDAY | 12 | Fantasy-comedy film about a mother and daughter who swap bodies (2 wds.) |
| 26% | CARROLLOCONNOR | 14 | Actor who starred on "All in the Family," a Norman Lear sitcom: 2 wds. |
| 26% | REGRETTINGYOU | 13 | 2019 bestseller by 41-Across about a mother and daughter coping with a family tragedy (2 wds.) |
| 26% | REBA | 4 | Sitcom about a Texas soccer mom |
| 26% | PHANTOMTHREAD | 13 | 2017 film about a fashion designer written and directed by Paul Thomas Anderson (2 wds.) |
| 26% | HOWTOWALKAWAY | 13 | Katherine Center novel about a plane crash survivor who falls in love with her physical therapist (4 wds.) |
| 26% | WHEREWEBELONG | 13 | Emily Giffin novel about a television producer reunited with the daughter she gave up for adoption (3 wds.) |
| 25% | SCHITTSCREEK | 12 | Sitcom set in Canada with a 2020 same-sex wedding between David and Patrick: 2 wds. |
| 25% | PATTILUPONE | 11 | She won two Tonys for Best Actress in a Musical, for "Evita" and "Gypsy": 2 wds. |
| 25% | ONEDAYATATIME | 13 | 1970s-'80s Norman Lear sitcom with the theme song "This Is It" (5 wds.) |
| 25% | BIGGIRL | 7 | 2010 book by Danielle Steel about a chubby little girl and her fight with self-esteem issues: 2 wds. |